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5tgz

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Current revision (16:50, 8 November 2023) (edit) (undo)
 
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<StructureSection load='5tgz' size='340' side='right'caption='[[5tgz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5tgz' size='340' side='right'caption='[[5tgz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tgz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desvh Desvh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TGZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tgz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._Hildenborough Desulfovibrio vulgaris str. Hildenborough] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TGZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZDG:4-[4-[2-(2,4-DICHLOROPHENYL)-4-METHYL-5-(PIPERIDIN-1-YLCARBAMOYL)PYRAZOL-3-YL]PHENYL]BUT-3-YNYL+NITRATE'>ZDG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CNR1, CNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=882 DESVH])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZDG:4-[4-[2-(2,4-DICHLOROPHENYL)-4-METHYL-5-(PIPERIDIN-1-YLCARBAMOYL)PYRAZOL-3-YL]PHENYL]BUT-3-YNYL+NITRATE'>ZDG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tgz OCA], [http://pdbe.org/5tgz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tgz RCSB], [http://www.ebi.ac.uk/pdbsum/5tgz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tgz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tgz OCA], [https://pdbe.org/5tgz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tgz RCSB], [https://www.ebi.ac.uk/pdbsum/5tgz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tgz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN]] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref>
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[https://www.uniprot.org/uniprot/FLAV_DESVH FLAV_DESVH] Low-potential electron donor to a number of redox enzymes.[https://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Desvh]]
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[[Category: Desulfovibrio vulgaris str. Hildenborough]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bohn, L M]]
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[[Category: Bohn LM]]
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[[Category: Han, G W]]
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[[Category: Han GW]]
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[[Category: Hanson, M A]]
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[[Category: Hanson MA]]
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[[Category: Ho, J H]]
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[[Category: Ho JH]]
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[[Category: Hua, T]]
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[[Category: Hua T]]
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[[Category: Korde, A]]
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[[Category: Korde A]]
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[[Category: Kufareva, I]]
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[[Category: Kufareva I]]
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[[Category: Laprairie, R B]]
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[[Category: Laprairie RB]]
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[[Category: Li, S]]
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[[Category: Li S]]
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[[Category: Liu, Z J]]
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[[Category: Liu ZJ]]
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[[Category: Makriyannis, A]]
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[[Category: Makriyannis A]]
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[[Category: Pu, M]]
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[[Category: Pu M]]
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[[Category: Qu, L]]
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[[Category: Qu L]]
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[[Category: Shui, W]]
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[[Category: Shui W]]
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[[Category: Stahl, E L]]
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[[Category: Stahl EL]]
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[[Category: Stevens, R C]]
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[[Category: Stevens RC]]
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[[Category: Vemuri, K]]
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[[Category: Vemuri K]]
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[[Category: Wu, B]]
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[[Category: Wu B]]
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[[Category: Wu, Y]]
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[[Category: Wu Y]]
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[[Category: Zhao, Q]]
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[[Category: Zhao Q]]
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[[Category: Zhao, S]]
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[[Category: Zhao S]]
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[[Category: Zhou, H]]
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[[Category: Zhou H]]
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[[Category: Zvonok, N]]
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[[Category: Zvonok N]]
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[[Category: Cb1-flavodoxin chimera]]
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[[Category: G protein-coupled receptor]]
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[[Category: Human cannabinoid receptor cb1]]
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[[Category: Lipidic cubic phase]]
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[[Category: Marijuana]]
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[[Category: Membrane protein]]
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[[Category: Signaling protein]]
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[[Category: Stabilizing antagonist am6538]]
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Current revision

Crystal Structure of the Human Cannabinoid Receptor CB1

PDB ID 5tgz

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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