6ujc

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==Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2==
==Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2==
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<StructureSection load='6ujc' size='340' side='right'caption='[[6ujc]], [[Resolution|resolution]] 3.56&Aring;' scene=''>
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<SX load='6ujc' size='340' side='right' viewer='molstar' caption='[[6ujc]], [[Resolution|resolution]] 3.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ujc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UJC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ujc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UJC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.56&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITGAV, MSK8, VNRA, VTNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ITGB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ujc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ujc OCA], [http://pdbe.org/6ujc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ujc RCSB], [http://www.ebi.ac.uk/pdbsum/6ujc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ujc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ujc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ujc OCA], [https://pdbe.org/6ujc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ujc RCSB], [https://www.ebi.ac.uk/pdbsum/6ujc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ujc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN]] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [[http://www.uniprot.org/uniprot/ITB8_HUMAN ITB8_HUMAN]] Integrin alpha-V/beta-8 is a receptor for fibronectin.
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6ujc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ujc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Integrin 3D structures|Integrin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Campbell, M G]]
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[[Category: Campbell MG]]
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[[Category: Cheng, Y]]
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[[Category: Cheng Y]]
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[[Category: Cormier, A]]
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[[Category: Cormier A]]
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[[Category: Nishimura, S L]]
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[[Category: Nishimura SL]]
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[[Category: Adhesion]]
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[[Category: Glycoprotein]]
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[[Category: Signaling]]
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[[Category: Signaling protein-immune system complex]]
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Current revision

Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2

6ujc, resolution 3.56Å

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