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5b1q

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Human herpesvirus 6B tegument protein U14

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 <StructureSection load='5b1q' size='340' side='right'caption='[[5b1q]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5b1q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-6_variant_b Hhv-6 variant b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B1Q FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5b1q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betaherpesvirus_6B Human betaherpesvirus 6B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B1Q FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">U14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32604 HHV-6 variant B])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1q OCA], [http://pdbe.org/5b1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b1q RCSB], [http://www.ebi.ac.uk/pdbsum/5b1q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1q ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1q OCA], [https://pdbe.org/5b1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b1q RCSB], [https://www.ebi.ac.uk/pdbsum/5b1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1q ProSAT]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/Q9WT50_HHV6Z Q9WT50_HHV6Z]
-The tegument protein U14 of human herpesvirus 6B (HHV-6B) constitutes the viral virion structure and is essential for viral growth. To define the characteristics and functions of U14, we determined the crystal structure of the N-terminal domain of HHV-6B U14 (U14-NTD) at 1.85 A resolution. U14-NTD forms an elongated helix-rich fold with a protruding beta hairpin. U14-NTD exists as a dimer exhibiting broad electrostatic interactions and a network of hydrogen bonds. This is first report of the crystal structure and dimerization of HHV-6B U14. The surface of the U14-NTD dimer reveals multiple clusters of negatively- and positively-charged residues that coincide with potential functional sites of U14. Three successive residues, L424, E425 and V426, which relate to viral growth, reside on the beta hairpin close to the dimer's two-fold axis. The hydrophobic side-chains of L424 and V426 that constitute a part of a hydrophobic patch are solvent-exposed, indicating the possibility that the beta hairpin region is a key functional site of HHV-6 U14. Structure-based sequence comparison suggests that U14-NTD corresponds to the core fold conserved among U14 homologs, human herpesvirus 7 U14, and human cytomegalovirus UL25 and UL35, although dimerization appears to be a specific feature of the U14 group.
-Crystal Structure of Human Herpesvirus 6B Tegument Protein U14.,Wang B, Nishimura M, Tang H, Kawabata A, Mahmoud NF, Khanlari Z, Hamada D, Tsuruta H, Mori Y PLoS Pathog. 2016 May 6;12(5):e1005594. doi: 10.1371/journal.ppat.1005594., eCollection 2016 May. PMID:27152739<ref>PMID:27152739</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 5b1q" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Hhv-6 variant b]]
+[[Category: Human betaherpesvirus 6B]]
 [[Category: Large Structures]]
-[[Category: Hamada, D]]
+[[Category: Hamada D]]
-[[Category: Kawabata, A]]
+[[Category: Kawabata A]]
-[[Category: Khanlari, Z]]
+[[Category: Khanlari Z]]
-[[Category: Mahmoud, N F]]
+[[Category: Mahmoud NF]]
-[[Category: Mori, Y]]
+[[Category: Mori Y]]
-[[Category: Nishimura, M]]
+[[Category: Nishimura M]]
-[[Category: Tang, H]]
+[[Category: Tang H]]
-[[Category: Tsuruta, H]]
+[[Category: Tsuruta H]]
-[[Category: Wang, B]]
+[[Category: Wang B]]
-[[Category: Herpesvirus]]
-[[Category: Homodimer]]
-[[Category: Tegument]]
-[[Category: Viral protein]]

5b1q

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Human herpesvirus 6B tegument protein U14

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