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| | <StructureSection load='5b1r' size='340' side='right'caption='[[5b1r]], [[Resolution|resolution]] 1.20Å' scene=''> | | <StructureSection load='5b1r' size='340' side='right'caption='[[5b1r]], [[Resolution|resolution]] 1.20Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5b1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B1R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5b1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B1R FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd72, Ly-32, Ly32, Lyb-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1r OCA], [http://pdbe.org/5b1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b1r RCSB], [http://www.ebi.ac.uk/pdbsum/5b1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1r ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1r OCA], [https://pdbe.org/5b1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b1r RCSB], [https://www.ebi.ac.uk/pdbsum/5b1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1r ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/CD72_MOUSE CD72_MOUSE]] Plays a role in B-cell proliferation and differentiation. | + | [https://www.uniprot.org/uniprot/CD72_MOUSE CD72_MOUSE] Plays a role in B-cell proliferation and differentiation. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Ito, N]] | + | [[Category: Ito N]] |
| - | [[Category: Numoto, N]] | + | [[Category: Numoto N]] |
| - | [[Category: Shinagawa, K]] | + | [[Category: Shinagawa K]] |
| - | [[Category: Tsubata, T]] | + | [[Category: Tsubata T]] |
| - | [[Category: B-cell]]
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| - | [[Category: C-type lectin]]
| + | |
| - | [[Category: Immune system]]
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| Structural highlights
Function
CD72_MOUSE Plays a role in B-cell proliferation and differentiation.
Publication Abstract from PubMed
Toll-like receptor 7 (TLR7) plays an essential role in development of systemic lupus erythematosus by co-stimulating B cells reactive to the endogenous TLR7 ligand Sm/ribonucleoprotein (RNP), a crucial lupus self-antigen. However, how the TLR7-mediated autoimmune response is regulated is not yet known. In this study, we demonstrate that CD72, an inhibitory B cell co-receptor known to prevent development of lupus, recognizes Sm/RNP at the extracellular C-type lectin-like domain (CTLD) and specifically inhibits B cell response to Sm/RNP. Moreover, the CTLD of CD72c, a lupus-susceptible allele, binds to Sm/RNP less strongly than that of lupus-resistant CD72a Reduced binding of CD72c is supported by x-ray crystallographic analysis that reveals a considerable alteration in charge at the putative ligand-binding site. Thus, CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP through CTLD-mediated recognition of Sm/RNP, thereby preventing production of anti-Sm/RNP antibody crucial for development of lupus.
CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP.,Akatsu C, Shinagawa K, Numoto N, Liu Z, Ucar AK, Aslam M, Phoon S, Adachi T, Furukawa K, Ito N, Tsubata T J Exp Med. 2016 Nov 14;213(12):2691-2706. Epub 2016 Oct 24. PMID:27810925[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Akatsu C, Shinagawa K, Numoto N, Liu Z, Ucar AK, Aslam M, Phoon S, Adachi T, Furukawa K, Ito N, Tsubata T. CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP. J Exp Med. 2016 Nov 14;213(12):2691-2706. Epub 2016 Oct 24. PMID:27810925 doi:http://dx.doi.org/10.1084/jem.20160560
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