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6afk

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Current revision (09:29, 22 November 2023) (edit) (undo)
 
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<StructureSection load='6afk' size='340' side='right'caption='[[6afk]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='6afk' size='340' side='right'caption='[[6afk]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6afk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseab Pseab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AFK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6afk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_UCBPP-PA14 Pseudomonas aeruginosa UCBPP-PA14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AFK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9WO:N-{(3S)-1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl}-1H-indole-2-carboxamide'>9WO</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trmD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208963 PSEAB])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9WO:N-{(3S)-1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl}-1H-indole-2-carboxamide'>9WO</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6afk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6afk OCA], [https://pdbe.org/6afk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6afk RCSB], [https://www.ebi.ac.uk/pdbsum/6afk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6afk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6afk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6afk OCA], [http://pdbe.org/6afk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6afk RCSB], [http://www.ebi.ac.uk/pdbsum/6afk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6afk ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRMD_PSEAB TRMD_PSEAB]] Specifically methylates guanosine-37 in various tRNAs.
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[https://www.uniprot.org/uniprot/TRMD_PSEAB TRMD_PSEAB] Specifically methylates guanosine-37 in various tRNAs.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6afk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6afk" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pseab]]
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[[Category: Pseudomonas aeruginosa UCBPP-PA14]]
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[[Category: Chionh, Y K]]
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[[Category: Chionh YK]]
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[[Category: Dedon, P C]]
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[[Category: Dedon PC]]
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[[Category: Hill, J]]
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[[Category: Hill J]]
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[[Category: Kang, C]]
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[[Category: Kang C]]
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[[Category: Koay, A]]
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[[Category: Koay A]]
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[[Category: Lescar, J]]
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[[Category: Lescar J]]
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[[Category: Matter, A]]
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[[Category: Matter A]]
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[[Category: McBee, M]]
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[[Category: McBee M]]
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[[Category: Nah, Q]]
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[[Category: Nah Q]]
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[[Category: Poulsen, A]]
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[[Category: Poulsen A]]
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[[Category: Sahili, A E]]
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[[Category: Sahili AE]]
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[[Category: Wong, Y W]]
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[[Category: Wong YW]]
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[[Category: Zhong, W]]
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[[Category: Zhong W]]
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[[Category: Transferase]]
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[[Category: Trna methyltransferase]]
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Current revision

Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor

PDB ID 6afk

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