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| | ==3D Solution Structure of S100A13== | | ==3D Solution Structure of S100A13== |
| - | <StructureSection load='2cxj' size='340' side='right'caption='[[2cxj]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2cxj' size='340' side='right'caption='[[2cxj]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2cxj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CXJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2cxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CXJ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cxj OCA], [http://pdbe.org/2cxj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cxj RCSB], [http://www.ebi.ac.uk/pdbsum/2cxj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cxj ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cxj OCA], [https://pdbe.org/2cxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cxj RCSB], [https://www.ebi.ac.uk/pdbsum/2cxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cxj ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/S10AD_MOUSE S10AD_MOUSE]] Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.<ref>PMID:12746488</ref> <ref>PMID:17991455</ref> <ref>PMID:11432880</ref> | + | [https://www.uniprot.org/uniprot/S10AD_MOUSE S10AD_MOUSE] Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.<ref>PMID:12746488</ref> <ref>PMID:17991455</ref> <ref>PMID:11432880</ref> |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Kumar, T K.S]] | + | [[Category: Kumar TKS]] |
| - | [[Category: Vaithiyalingam, S]] | + | [[Category: Vaithiyalingam S]] |
| - | [[Category: Yu, C]] | + | [[Category: Yu C]] |
| - | [[Category: Calcium]]
| + | |
| - | [[Category: Fgf]]
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| - | [[Category: Metal binding protein]]
| + | |
| - | [[Category: Non-classical secretion]]
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| - | [[Category: S100a13]]
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| - | [[Category: Solution]]
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| Structural highlights
Function
S10AD_MOUSE Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.[1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
See Also
References
- ↑ Mandinova A, Soldi R, Graziani I, Bagala C, Bellum S, Landriscina M, Tarantini F, Prudovsky I, Maciag T. S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells. J Cell Sci. 2003 Jul 1;116(Pt 13):2687-96. Epub 2003 May 13. PMID:12746488 doi:http://dx.doi.org/10.1242/jcs.00471
- ↑ Kathir KM, Ibrahim K, Rajalingam D, Prudovsky I, Yu C, Kumar TK. S100A13-lipid interactions-role in the non-classical release of the acidic fibroblast growth factor. Biochim Biophys Acta. 2007 Dec;1768(12):3080-9. Epub 2007 Sep 25. PMID:17991455 doi:http://dx.doi.org/10.1016/j.bbamem.2007.09.007
- ↑ Landriscina M, Bagala C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T. Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. J Biol Chem. 2001 Jul 6;276(27):25549-57. Epub 2001 May 10. PMID:11432880 doi:http://dx.doi.org/10.1074/jbc.M102925200
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