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5r4r

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(New page: '''Unreleased structure''' The entry 5r4r is ON HOLD Authors: Kidd, S.L., Mateu, N., Talon, R., Krojer, T., Aimon, A., Bradley, A.R., Fairhead, M., Díaz...)
Current revision (11:35, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5r4r is ON HOLD
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==PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with EN08775-42==
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<StructureSection load='5r4r' size='340' side='right'caption='[[5r4r]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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Authors: Kidd, S.L., Mateu, N., Talon, R., Krojer, T., Aimon, A., Bradley, A.R., Fairhead, M., Díaz-Sáez, L., Sore, H.F., Madin, A., Huber, K.V.M., von Delft, F., Spring, D.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5r4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5R4R FirstGlance]. <br>
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Description: PanDDA analysis group deposition --Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with EN08775-42
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RWA:(5R)-3,3,5-trimethyl-5-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]pyrrolidine-2,4-dione'>RWA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Spring, D.R]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4r OCA], [https://pdbe.org/5r4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5r4r RCSB], [https://www.ebi.ac.uk/pdbsum/5r4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4r ProSAT]</span></td></tr>
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[[Category: DãƒÆ’ƒÀšÃ‚­Az-SãƒÆ’ƒÀšÃ‚¡Ez, L]]
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</table>
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[[Category: Aimon, A]]
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== Function ==
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[[Category: Mateu, N]]
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[https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>
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[[Category: Kidd, S.L]]
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== References ==
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[[Category: Madin, A]]
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<references/>
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[[Category: Fairhead, M]]
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__TOC__
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[[Category: Von Delft, F]]
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</StructureSection>
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[[Category: Bradley, A.R]]
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[[Category: Homo sapiens]]
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[[Category: Talon, R]]
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[[Category: Large Structures]]
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[[Category: Huber, K.V.M]]
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[[Category: Aimon A]]
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[[Category: Sore, H.F]]
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[[Category: Bradley AR]]
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[[Category: Krojer, T]]
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[[Category: Diaz-Saez L]]
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[[Category: Fairhead M]]
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[[Category: Huber KVM]]
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[[Category: Kidd SL]]
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[[Category: Krojer T]]
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[[Category: Madin A]]
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[[Category: Mateu N]]
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[[Category: Sore HF]]
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[[Category: Spring DR]]
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[[Category: Talon R]]
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[[Category: Von Delft F]]

Current revision

PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with EN08775-42

PDB ID 5r4r

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