6rs4

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<StructureSection load='6rs4' size='340' side='right'caption='[[6rs4]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='6rs4' size='340' side='right'caption='[[6rs4]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rs4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RS4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rs4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Catharanthus_roseus Catharanthus roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RS4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rs4 OCA], [http://pdbe.org/6rs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rs4 RCSB], [http://www.ebi.ac.uk/pdbsum/6rs4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rs4 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rs4 OCA], [https://pdbe.org/6rs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rs4 RCSB], [https://www.ebi.ac.uk/pdbsum/6rs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rs4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TS_CATRO TS_CATRO]] Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to tabersonine, a precursor of vindoline.<ref>PMID:29511102</ref> <ref>PMID:29724909</ref>
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[https://www.uniprot.org/uniprot/TS_CATRO TS_CATRO] Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to tabersonine, a precursor of vindoline.<ref>PMID:29511102</ref> <ref>PMID:29724909</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Catharanthus roseus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bussey, K]]
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[[Category: Bussey K]]
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[[Category: Caputi, L]]
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[[Category: Caputi L]]
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[[Category: Connor, S E.O]]
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[[Category: Curcino Vieira IJ]]
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[[Category: Farrow, S C]]
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[[Category: Farrow SC]]
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[[Category: Franke, J]]
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[[Category: Franke J]]
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[[Category: Lawson, D M]]
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[[Category: Lawson DM]]
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[[Category: Stevenson, C E.M]]
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[[Category: O'Connor SE]]
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[[Category: Vieira, I J.Curcino]]
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[[Category: Stevenson CEM]]
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[[Category: Alkaloid]]
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[[Category: Alpha/beta hydrolase fold]]
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[[Category: Biosynthesis]]
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[[Category: Hydrolase]]
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[[Category: Natural product]]
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[[Category: Tabersonine]]
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Current revision

Structure of tabersonine synthase - an alpha-beta hydrolase from Catharanthus roseus

PDB ID 6rs4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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