6tlm

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<StructureSection load='6tlm' size='340' side='right'caption='[[6tlm]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
<StructureSection load='6tlm' size='340' side='right'caption='[[6tlm]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6tlm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TLM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6tlm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TLM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MJE:4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic+acid'>MJE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.321&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tlm OCA], [http://pdbe.org/6tlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tlm RCSB], [http://www.ebi.ac.uk/pdbsum/6tlm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tlm ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MJE:4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic+acid'>MJE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tlm OCA], [https://pdbe.org/6tlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tlm RCSB], [https://www.ebi.ac.uk/pdbsum/6tlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tlm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brunsveld, L]]
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[[Category: Brunsveld L]]
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[[Category: Meijer, F A]]
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[[Category: Meijer FA]]
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[[Category: Vries, R M.J M.de]]
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[[Category: De Vries RMJM]]
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[[Category: Allosteric]]
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[[Category: Gene regulation]]
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[[Category: Inhibitor]]
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[[Category: Inverse agonist]]
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[[Category: Nuclear receptor]]
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Current revision

ROR(gamma)t ligand binding domain in complex with allosteric ligand compound 13 (Glenmark)

PDB ID 6tlm

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