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| | <StructureSection load='6kh0' size='340' side='right'caption='[[6kh0]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='6kh0' size='340' side='right'caption='[[6kh0]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6kh0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Kuruma_prawn Kuruma prawn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KH0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6kh0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Penaeus_japonicus Penaeus japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KH0 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kh0 OCA], [http://pdbe.org/6kh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kh0 RCSB], [http://www.ebi.ac.uk/pdbsum/6kh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kh0 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kh0 OCA], [https://pdbe.org/6kh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kh0 RCSB], [https://www.ebi.ac.uk/pdbsum/6kh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kh0 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/T2B7E1_PENJP T2B7E1_PENJP]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145] | + | [https://www.uniprot.org/uniprot/T2B7E1_PENJP T2B7E1_PENJP] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 6kh0" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 6kh0" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Ferritin 3D structures|Ferritin 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Ferroxidase]] | |
| - | [[Category: Kuruma prawn]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Gu, C]] | + | [[Category: Penaeus japonicus]] |
| - | [[Category: Zhang, T]] | + | [[Category: Gu C]] |
| - | [[Category: Zhao, G]] | + | [[Category: Zhang T]] |
| - | [[Category: Metal binding protein]] | + | [[Category: Zhao G]] |
| Structural highlights
Function
T2B7E1_PENJP Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145]
Publication Abstract from PubMed
Metal-organic frameworks (MOFs) hold great promise for numerous applications. However, proteins, carriers of biological functions in living systems, have not yet been fully explored as building blocks for the construction of MOFs. Here, we presented a strategy for the fabrication of binary MOFs. Considering octahedral ferritin symmetry, we firstly incorporated four His 2 (His-His) motifs into the exterior surface of ferritin nanocage nearby each C 4 channel, yielding protein linkers with multiple metal binding sites (bisH-SF). Secondly, by adding nickel ions to bisH-SF solutions to triggers the self-assembly of ferritin nanocages into a porous 3D crystalline MOF with designed protein lattice, where two adjacent ferritin molecules along the C 4 symmetry axes are bridged by four dinuclear or tetranuclear nickel clusters depending on Ni 2+ concentration. This work provides a simple approach for precise control over a binary protein-metal crystalline framework, and resulting MOFs exhibited inherent ferroxidase activity and peroxidase-like catalytic activity.
Structural Insight into Binary Protein MOFs with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes.,Gu C, Chen H, Wang Y, Zhang T, Wang H, Zhao G Chemistry. 2019 Dec 9. doi: 10.1002/chem.201905315. PMID:31820500[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Gu C, Chen H, Wang Y, Zhang T, Wang H, Zhao G. Structural Insight into Binary Protein MOFs with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes. Chemistry. 2019 Dec 9. doi: 10.1002/chem.201905315. PMID:31820500 doi:http://dx.doi.org/10.1002/chem.201905315
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