6ulx

<table><tr><td colspan='2'>[[6ulx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_stratosphericus_lama_585 Bacillus stratosphericus lama 585]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ULX FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QA7:5-O-{(S)-hydroxy[(4-methyl-2-oxopentanoyl)oxy]phosphoryl}adenosine'>QA7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C883_1060 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1236481 Bacillus stratosphericus LAMA 585])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ulx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ulx OCA], [http://pdbe.org/6ulx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ulx RCSB], [http://www.ebi.ac.uk/pdbsum/6ulx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ulx ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Nonribosomal depsipeptides are natural products composed of amino and hydroxy acid residues. The hydroxy acid residues often derive from alpha-keto acids, reduced by ketoreductase domains in the depsipeptide synthetases. Biochemistry and structures reveal the mechanism of discrimination for alpha-keto acids and a remarkable architecture: flanking intact adenylation and ketoreductase domains are sequences separated by &gt;1,100 residues that form a split 'pseudoAsub' domain, structurally important for the depsipeptide module's synthetic cycle.

 

Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis.,Alonzo DA, Chiche-Lapierre C, Tarry MJ, Wang J, Schmeing TM Nat Chem Biol. 2020 Feb 17. pii: 10.1038/s41589-020-0481-5. doi:, 10.1038/s41589-020-0481-5. PMID:32066969<ref>PMID:32066969</ref>

 

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<references/>

[[Category: Bacillus stratosphericus lama 585]]

[[Category: Alonzo, D A]]

[[Category: Chiche-Lapierre, C]]

[[Category: Schmeing, T M]]

[[Category: Valinomycin]]