2d5r

<table><tr><td colspan='2'>[[2d5r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D5R FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d5r OCA], [http://pdbe.org/2d5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d5r RCSB], [http://www.ebi.ac.uk/pdbsum/2d5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2d5r ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CNOT7_HUMAN CNOT7_HUMAN]] Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). [[http://www.uniprot.org/uniprot/TOB1_HUMAN TOB1_HUMAN]] Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors.

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== Publication Abstract from PubMed ==

The Tob/BTG family is a group of antiproliferative proteins containing two highly homologous regions, Box A and Box B. These proteins all associate with CCR4-associated factor 1 (Caf1), which belongs to the ribonuclease D (RNase D) family of deadenylases and is a component of the CCR4-Not deadenylase complex. Here we determined the crystal structure of the complex of the N-terminal region of Tob and human Caf1 (hCaf1). Tob exhibited a novel fold, whereas hCaf1 most closely resembled the catalytic domain of yeast Pop2 and human poly(A)-specific ribonuclease. Interestingly, the association of hCaf1 was mediated by both Box A and Box B of Tob. Cell growth assays using both wild-type and mutant proteins revealed that deadenylase activity of Caf1 is not critical but complex formation is crucial to cell growth inhibition. Caf1 tethers Tob to the CCR4-Not deadenylase complex, and thereby Tob gathers several factors at its C-terminal region, such as poly(A)-binding proteins, to exert antiproliferative activity.

Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.,Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F J Biol Chem. 2009 May 8;284(19):13244-55. Epub 2009 Mar 10. PMID:19276069<ref>PMID:19276069</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Human]]

[[Category: Horiuchi, M]]

[[Category: Ikematsu, N]]

[[Category: Inagaki, F]]

[[Category: Kawamura-Tsuzuku, J]]

[[Category: Muroya, N]]

[[Category: Nakamura, T]]

[[Category: Nishida, M]]

[[Category: Suzuki, N N]]

[[Category: Takahasi, K]]

[[Category: Yamamoto, T]]

[[Category: Yoshida, Y]]

[[Category: Transcription]]