5l35

<table><tr><td colspan='2'>[[5l35]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_phage_sf6 Shigella phage sf6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L35 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l35 OCA], [http://pdbe.org/5l35 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l35 RCSB], [http://www.ebi.ac.uk/pdbsum/5l35 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l35 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The enormous prevalence of tailed DNA bacteriophages on this planet is enabled by highly efficient self-assembly of hundreds of protein subunits into highly stable capsids. These capsids can stand with an internal pressure as high as approximately 50 atmospheres as a result of the phage DNA-packaging process. Here we report the complete atomic model of the headful DNA-packaging bacteriophage Sf6 at 2.9 A resolution determined by electron cryo-microscopy. The structure reveals the DNA-inflated, tensed state of a robust protein shell assembled via noncovalent interactions. Remarkable global conformational polymorphism of capsid proteins, a network formed by extended N arms, mortise-and-tenon-like intercapsomer joints, and abundant beta-sheet-like mainchain:mainchain intermolecular interactions, confers significant strength yet also flexibility required for capsid assembly and DNA packaging. Differential formations of the hexon and penton are mediated by a drastic alpha-helix-to-beta-strand structural transition. The assembly scheme revealed here may be common among tailed DNA phages and herpesviruses.

 

Structure of a headful DNA-packaging bacterial virus at 2.9 A resolution by electron cryo-microscopy.,Zhao H, Li K, Lynn AY, Aron KE, Yu G, Jiang W, Tang L Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201615025. doi:, 10.1073/pnas.1615025114. PMID:28320961<ref>PMID:28320961</ref>

 

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<references/>

[[Category: Shigella phage sf6]]

[[Category: Tang, L]]

[[Category: Zhao, H]]

[[Category: Virus]]