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3zue

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Current revision (10:43, 9 May 2024) (edit) (undo)
 
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<SX load='3zue' size='340' side='right' viewer='molstar' caption='[[3zue]], [[Resolution|resolution]] 10.30&Aring;' scene=''>
<SX load='3zue' size='340' side='right' viewer='molstar' caption='[[3zue]], [[Resolution|resolution]] 10.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zue]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhdv Rhdv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZUE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zue]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabbit_hemorrhagic_disease_virus Rabbit hemorrhagic disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUE FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zue OCA], [http://pdbe.org/3zue PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zue RCSB], [http://www.ebi.ac.uk/pdbsum/3zue PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zue ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zue OCA], [https://pdbe.org/3zue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zue RCSB], [https://www.ebi.ac.uk/pdbsum/3zue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zue ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLG_RHDVA POLG_RHDVA] NTPase presumably plays a role in replication. Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity). 3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved. RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).[PROSITE-ProRule:PRU00539] Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Virus coat protein|Virus coat protein]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Rhdv]]
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[[Category: Rabbit hemorrhagic disease virus]]
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[[Category: Angulo, I]]
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[[Category: Angulo I]]
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[[Category: Barcena, J]]
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[[Category: Barcena J]]
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[[Category: Carrascosa, J L]]
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[[Category: Carrascosa JL]]
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[[Category: Caston, J R]]
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[[Category: Caston JR]]
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[[Category: Chichon, J]]
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[[Category: Chichon J]]
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[[Category: Gomez-Blanco, J]]
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[[Category: Gomez-Blanco J]]
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[[Category: Gonzalez, J M]]
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[[Category: Gonzalez JM]]
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[[Category: Luque, D]]
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[[Category: Luque D]]
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[[Category: Marabini, R]]
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[[Category: Marabini R]]
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[[Category: Mena, I]]
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[[Category: Mena I]]
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[[Category: Trus, B L]]
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[[Category: Trus BL]]
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[[Category: Verdaguer, N]]
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[[Category: Verdaguer N]]
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[[Category: Cage design]]
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[[Category: Molecular switch]]
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[[Category: Protein engineering]]
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[[Category: Structural polymorphism]]
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[[Category: Virus]]
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[[Category: Virus assembly]]
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Current revision

Rabbit Hemorrhagic Disease Virus (RHDV)capsid protein

3zue, resolution 10.30Å

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OCA

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