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5h0r

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RNA dependent RNA polymerase ,vp4,dsRNA

5h0r, resolution 3.90Å

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Retrieved from "http://52.214.119.220/wiki/index.php/5h0r"

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 <SX load='5h0r' size='340' side='right' viewer='molstar' caption='[[5h0r]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5h0r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bmcpv Bmcpv] and [http://en.wikipedia.org/wiki/Dendrolimus_punctatus_cypovirus Dendrolimus punctatus cypovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H0R FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5h0r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori_cypovirus_1 Bombyx mori cypovirus 1], [https://en.wikipedia.org/wiki/Cypovirus Cypovirus] and [https://en.wikipedia.org/wiki/Dendrolimus_punctatus_cypovirus_1 Dendrolimus punctatus cypovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H0R FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h0s|5h0s]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RdRp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=110829 BmCPV])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h0r OCA], [https://pdbe.org/5h0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h0r RCSB], [https://www.ebi.ac.uk/pdbsum/5h0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h0r ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h0r OCA], [http://pdbe.org/5h0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h0r RCSB], [http://www.ebi.ac.uk/pdbsum/5h0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h0r ProSAT]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/A0A0S1LIW6_CPVBM A0A0S1LIW6_CPVBM]
-Single-particle cryo-electron microscopy (cryo-EM) allows the high-resolution structural determination of biological assemblies in a near-native environment. However, all high-resolution (better than 3.5A) cryo-EM structures reported to date were obtained by using 300kV transmission electron microscopes (TEMs). We report here the structures of a cypovirus capsid of 750-A diameter at 3.3-A resolution and of RNA-dependent RNA polymerase (RdRp) complexes within the capsid at 3.9-A resolution using a 200-kV TEM. The newly resolved structure revealed conformational changes of two subdomains in the RdRp. These conformational changes, which were involved in RdRp's switch from non-transcribing to transcribing mode, suggest that the RdRp may facilitate the unwinding of genomic double-stranded RNA. The possibility of 3-A resolution structural determinations for biological assemblies of relatively small sizes using cryo-EM at 200kV was discussed.
-Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV.,Li X, Zhou N, Chen W, Zhu B, Wang X, Xu B, Wang J, Liu H, Cheng L J Mol Biol. 2017 Jan 6;429(1):79-87. doi: 10.1016/j.jmb.2016.11.025. Epub 2016, Dec 1. PMID:27914893<ref>PMID:27914893</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 5h0r" style="background-color:#fffaf0;"></div>
 ==See Also==
 *[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
-== References ==
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-<references/>
 __TOC__
 </SX>
-[[Category: Bmcpv]]
+[[Category: Bombyx mori cypovirus 1]]
-[[Category: Dendrolimus punctatus cypovirus]]
+[[Category: Cypovirus]]
+[[Category: Dendrolimus punctatus cypovirus 1]]
 [[Category: Large Structures]]
-[[Category: Chen, W]]
+[[Category: Chen W]]
-[[Category: Cheng, L]]
+[[Category: Cheng L]]
-[[Category: Li, X]]
+[[Category: Li X]]
-[[Category: Liu, H]]
+[[Category: Liu H]]
-[[Category: Wang, J]]
+[[Category: Wang J]]
-[[Category: Wang, X]]
+[[Category: Wang X]]
-[[Category: Xu, B]]
+[[Category: Xu B]]
-[[Category: Zhou, N]]
+[[Category: Zhou N]]
-[[Category: Zhu, B]]
+[[Category: Zhu B]]
-[[Category: Structural classification]]
-[[Category: Transferase-rna complex]]

5h0r

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RNA dependent RNA polymerase ,vp4,dsRNA

Structural highlights

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