6lqi

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<SX load='6lqi' size='340' side='right' viewer='molstar' caption='[[6lqi]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
<SX load='6lqi' size='340' side='right' viewer='molstar' caption='[[6lqi]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6lqi]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LQI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6lqi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LQI FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lqi OCA], [http://pdbe.org/6lqi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lqi RCSB], [http://www.ebi.ac.uk/pdbsum/6lqi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lqi ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lqi OCA], [https://pdbe.org/6lqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lqi RCSB], [https://www.ebi.ac.uk/pdbsum/6lqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lqi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PIEZ1_MOUSE PIEZ1_MOUSE]] Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.<ref>PMID:20813920</ref> <ref>PMID:22343900</ref> <ref>PMID:24157948</ref> <ref>PMID:24958852</ref> <ref>PMID:25119035</ref>
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[https://www.uniprot.org/uniprot/PIEZ1_MOUSE PIEZ1_MOUSE] Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.<ref>PMID:20813920</ref> <ref>PMID:22343900</ref> <ref>PMID:24157948</ref> <ref>PMID:24958852</ref> <ref>PMID:25119035</ref>
== References ==
== References ==
<references/>
<references/>
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Geng, J]]
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[[Category: Mus musculus]]
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[[Category: Li, X]]
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[[Category: Geng J]]
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[[Category: Liu, W]]
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[[Category: Li X]]
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[[Category: Shen, B]]
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[[Category: Liu W]]
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[[Category: Wang, L]]
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[[Category: Shen B]]
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[[Category: Xiao, B]]
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[[Category: Wang L]]
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[[Category: Zhang, M]]
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[[Category: Xiao B]]
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[[Category: Zhang, T]]
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[[Category: Zhang M]]
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[[Category: Zhou, H]]
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[[Category: Zhang T]]
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[[Category: Isoform]]
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[[Category: Zhou H]]
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[[Category: Mechanogating]]
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[[Category: Mechanotransduction channel]]
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[[Category: Membrane protein]]
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[[Category: Piezo1 1]]
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Current revision

Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1

6lqi, resolution 4.50Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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