6mhx

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<SX load='6mhx' size='340' side='right' viewer='molstar' caption='[[6mhx]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
<SX load='6mhx' size='340' side='right' viewer='molstar' caption='[[6mhx]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mhx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MHX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mhx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MHX FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPV3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mhx OCA], [http://pdbe.org/6mhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mhx RCSB], [http://www.ebi.ac.uk/pdbsum/6mhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mhx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mhx OCA], [https://pdbe.org/6mhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mhx RCSB], [https://www.ebi.ac.uk/pdbsum/6mhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mhx ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN]] Mutilating palmoplantar keratoderma with periorificial keratotic plaques. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Mutilating palmoplantar keratoderma with periorificial keratotic plaques. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).<ref>PMID:12077604</ref> <ref>PMID:12077606</ref> <ref>PMID:21593771</ref>
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[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).<ref>PMID:12077604</ref> <ref>PMID:12077606</ref> <ref>PMID:21593771</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6mhx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6mhx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</SX>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Borschel, W F]]
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[[Category: Borschel WF]]
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[[Category: Herzik, M A]]
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[[Category: Herzik MA]]
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[[Category: Hirschi, M]]
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[[Category: Hirschi M]]
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[[Category: Lander, G C]]
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[[Category: Lander GC]]
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[[Category: Lee, S Y]]
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[[Category: Lee SY]]
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[[Category: Song, A]]
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[[Category: Song A]]
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[[Category: Wu, M]]
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[[Category: Wu M]]
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[[Category: Zubcevic, L]]
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[[Category: Zubcevic L]]
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[[Category: Calcium transport]]
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[[Category: Ion channel]]
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[[Category: Membrane protein]]
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[[Category: Transport protein]]
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[[Category: Trp channel]]
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Current revision

Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (2)

6mhx, resolution 4.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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