6nbh
From Proteopedia
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<SX load='6nbh' size='340' side='right' viewer='molstar' caption='[[6nbh]], [[Resolution|resolution]] 3.50Å' scene=''> | <SX load='6nbh' size='340' side='right' viewer='molstar' caption='[[6nbh]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6nbh]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6nbh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NBH FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbh OCA], [https://pdbe.org/6nbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nbh RCSB], [https://www.ebi.ac.uk/pdbsum/6nbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbh ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] Blomstrand lethal chondrodysplasia;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/GBB1_RAT GBB1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref> [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</SX> | </SX> | ||
| - | [[Category: | + | [[Category: Bos taurus]] |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Synthetic construct | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Clark | + | [[Category: Synthetic construct]] |
| - | [[Category: Gardella | + | [[Category: Clark LJ]] |
| - | [[Category: Jean-Alphonse | + | [[Category: Gardella TJ]] |
| - | [[Category: Jiang | + | [[Category: Jean-Alphonse FG]] |
| - | [[Category: Kang | + | [[Category: Jiang Y]] |
| - | [[Category: Li | + | [[Category: Kang Y]] |
| - | [[Category: Ma | + | [[Category: Li C-Y]] |
| - | [[Category: Melcher | + | [[Category: Ma S]] |
| - | [[Category: Shen | + | [[Category: Melcher K]] |
| - | [[Category: Sutkeviciute | + | [[Category: Shen D-D]] |
| - | [[Category: Vilardaga | + | [[Category: Sutkeviciute I]] |
| - | + | [[Category: Vilardaga J-P]] | |
| - | [[Category: Wang | + | [[Category: Wang M-W]] |
| - | [[Category: Watanabe | + | [[Category: Watanabe T]] |
| - | [[Category: White | + | [[Category: White AD]] |
| - | [[Category: Xiao | + | [[Category: Xiao K]] |
| - | [[Category: Xu | + | [[Category: Xu HE]] |
| - | [[Category: Yang | + | [[Category: Yang D]] |
| - | [[Category: Zhang | + | [[Category: Zhang Y]] |
| - | [[Category: Zhao | + | [[Category: Zhao L-H]] |
| - | [[Category: Zhou | + | [[Category: Zhou XE]] |
| - | [[Category: | + | [[Category: De Waal PP]] |
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Current revision
Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein
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Categories: Bos taurus | Homo sapiens | Large Structures | Rattus norvegicus | Synthetic construct | Clark LJ | Gardella TJ | Jean-Alphonse FG | Jiang Y | Kang Y | Li C-Y | Ma S | Melcher K | Shen D-D | Sutkeviciute I | Vilardaga J-P | Wang M-W | Watanabe T | White AD | Xiao K | Xu HE | Yang D | Zhang Y | Zhao L-H | Zhou XE | De Waal PP
