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6ola

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<SX load='6ola' size='340' side='right' viewer='molstar' caption='[[6ola]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<SX load='6ola' size='340' side='right' viewer='molstar' caption='[[6ola]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ola]] is a 120 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Pcv2 Pcv2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OLA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ola]] is a 120 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_circovirus_2 Porcine circovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OLA FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85708 PCV2])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ola FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ola OCA], [http://pdbe.org/6ola PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ola RCSB], [http://www.ebi.ac.uk/pdbsum/6ola PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ola ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ola FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ola OCA], [https://pdbe.org/6ola PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ola RCSB], [https://www.ebi.ac.uk/pdbsum/6ola PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ola ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G0ZPI6_PCV2 G0ZPI6_PCV2]
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Porcine circovirus 2 (PCV2) has a major impact on the swine industry. Eight PCV2 genotypes (a-h) have been identified using capsid sequence analysis. PCV2d has been designated as the emerging genotype. The cryo-electron microscopy molecular envelope of PCV2d virus-like particles identifies differences between PCV2a, b and d genotypes that accompany the emergence of PCV2b from PCV2a, and PCV2d from PCV2b. These differences indicate that sequence analysis of genotypes is insufficient, and that it is important to determine the PCV2 capsid structure as the virus evolves. Structure-based sequence comparison demonstrate that each genotype possesses a unique combination of amino acids located on the surface of the capsid that undergo substitution. We also demonstrate that the capsid N-terminus moves in response to increasing amount of nucleic acid packaged into the capsid. Furthermore, we model a tetranucleotide between the 5- and 2-fold axes of symmetry that appears to be responsible for capsid stability.
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Structural characterization of the PCV2d virus-like particle at 3.3A resolution reveals differences to PCV2a and PCV2b capsids, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes.,Khayat R, Wen K, Alimova A, Gavrilov B, Katz A, Galarza JM, Gottlieb P Virology. 2019 Nov;537:186-197. doi: 10.1016/j.virol.2019.09.001. Epub 2019 Sep, 3. PMID:31505320<ref>PMID:31505320</ref>
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6ola" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pcv2]]
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[[Category: Porcine circovirus 2]]
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[[Category: Alimova, A]]
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[[Category: Alimova A]]
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[[Category: Galarza, J]]
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[[Category: Galarza J]]
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[[Category: Gottlieb, P]]
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[[Category: Gottlieb P]]
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[[Category: Khayat, R]]
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[[Category: Khayat R]]
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[[Category: Wen, K]]
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[[Category: Wen K]]
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[[Category: Circovirus]]
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[[Category: Viral jelly roll]]
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[[Category: Virus like particle]]
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Current revision

Structure of the PCV2d virus-like particle

6ola, resolution 3.30Å

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