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6p5j

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<SX load='6p5j' size='340' side='right' viewer='molstar' caption='[[6p5j]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<SX load='6p5j' size='340' side='right' viewer='molstar' caption='[[6p5j]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6p5j]] is a 81 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P5J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P5J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6p5j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P5J FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6p4g|6p4g]], [[6p4h|6p4h]], [[6p5i|6p5i]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p5j OCA], [http://pdbe.org/6p5j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p5j RCSB], [http://www.ebi.ac.uk/pdbsum/6p5j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p5j ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p5j OCA], [https://pdbe.org/6p5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p5j RCSB], [https://www.ebi.ac.uk/pdbsum/6p5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p5j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
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[https://www.uniprot.org/uniprot/G1SP51_RABIT G1SP51_RABIT]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Colony collapse disorder (CCD) is a multi-faceted syndrome decimating bee populations worldwide, and a group of viruses of the widely distributed Dicistroviridae family have been identified as a causing agent of CCD. This family of viruses employs non-coding RNA sequences, called internal ribosomal entry sites (IRESs), to precisely exploit the host machinery for viral protein production. Using single-particle cryo-electron microscopy (cryo-EM), we have characterized how the IRES of Israeli acute paralysis virus (IAPV) intergenic region captures and redirects translating ribosomes toward viral RNA messages. We reconstituted two in vitro reactions targeting a pre-translocation and a post-translocation state of the IAPV-IRES in the ribosome, allowing us to identify six structures using image processing classification methods. From these, we reconstructed the trajectory of IAPV-IRES from the early small subunit recruitment to the final post-translocated state in the ribosome. An early commitment of IRES/ribosome complexes for global pre-translocation mimicry explains the high efficiency observed for this IRES. Efforts directed toward fighting CCD by targeting the IAPV-IRES using RNA-interference technology are underway, and the structural framework presented here may assist in further refining these approaches.
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The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.,Acosta-Reyes F, Neupane R, Frank J, Fernandez IS EMBO J. 2019 Oct 14:e102226. doi: 10.15252/embj.2019102226. PMID:31609474<ref>PMID:31609474</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6p5j" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Acosta-Reyes, F J]]
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[[Category: Acosta-Reyes FJ]]
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[[Category: Fernandez, I S]]
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[[Category: Fernandez IS]]
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[[Category: Frank, J]]
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[[Category: Frank J]]
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[[Category: Neupane, R]]
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[[Category: Neupane R]]
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[[Category: Internal ribosome entry site]]
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[[Category: Ire]]
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[[Category: Israeli acute paralysis virus]]
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[[Category: Large ribosomal subunit]]
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[[Category: Ribosome]]
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[[Category: Small ribosomal subunit]]
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Current revision

Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2)

6p5j, resolution 3.10Å

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