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6p7w

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<SX load='6p7w' size='340' side='right' viewer='molstar' caption='[[6p7w]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<SX load='6p7w' size='340' side='right' viewer='molstar' caption='[[6p7w]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6p7w]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_56498 Atcc 56498]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P7W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6p7w]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P7W FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLLA0_E03807g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 ATCC 56498]), KLLA0_F13816g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 ATCC 56498]), SKP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 ATCC 56498]), KLLA0_D09977g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 ATCC 56498])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p7w OCA], [http://pdbe.org/6p7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p7w RCSB], [http://www.ebi.ac.uk/pdbsum/6p7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p7w ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p7w OCA], [https://pdbe.org/6p7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p7w RCSB], [https://www.ebi.ac.uk/pdbsum/6p7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p7w ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6CPM4_KLULA Q6CPM4_KLULA]
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Kinetochores are the multiprotein complexes that link chromosomal centromeres to mitotic-spindle microtubules. Budding yeast centromeres comprise three sequential "centromere-determining elements", CDEI, II, and III. CDEI (8 bp) and CDEIII (~25 bp) are conserved between Kluyveromyces lactis and Saccharomyces cerevisiae, but CDEII in the former is twice as long (160 bp) as CDEII in the latter (80 bp). The CBF3 complex recognizes CDEIII and is required for assembly of a centromeric nucleosome, which in turn recruits other kinetochore components. To understand differences in centromeric nucleosome assembly between K. lactis and S. cerevisiae, we determined the structure of a K. lactis CBF3 complex by electron cryomicroscopy at ~4 A resolution and compared it with published structures of S. cerevisiae CBF3. We show differences in the pose of Ndc10 and discuss potential models of the K. lactis centromeric nucleosome that account for the extended CDEII length.
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Structure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis.,Lee PD, Wei H, Tan D, Harrison SC J Mol Biol. 2019 Aug 17. pii: S0022-2836(19)30506-6. doi:, 10.1016/j.jmb.2019.08.003. PMID:31425683<ref>PMID:31425683</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6p7w" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Atcc 56498]]
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[[Category: Kluyveromyces lactis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Harrison, S C]]
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[[Category: Harrison SC]]
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[[Category: Lee, P D]]
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[[Category: Lee PD]]
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[[Category: Tan, D]]
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[[Category: Tan D]]
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[[Category: Wei, H]]
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[[Category: Wei H]]
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[[Category: Dna binding protein]]
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[[Category: Yeast centromere-binding complex]]
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Current revision

Structure of the K. lactis CBF3 core - Ndc10 D1 complex

6p7w, resolution 4.10Å

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OCA

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