1hbi

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(New page: 200px<br /> <applet load="1hbi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hbi, resolution 1.7&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1hbi.gif|left|200px]]<br />
 
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<applet load="1hbi" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hbi, resolution 1.7&Aring;" />
 
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'''CRYSTAL STRUCTURE OF OXYGENATED SCAPHARCA DIMERIC HEMOGLOBIN AT 1.7 ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF OXYGENATED SCAPHARCA DIMERIC HEMOGLOBIN AT 1.7 ANGSTROMS RESOLUTION==
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The crystal structure of the cooperative dimeric hemoglobin from the blood, clam Scapharca inaequivalvis has been determined in the oxygenated state, and refined to an R-factor of 0.157 at 1.7-A resolution. The structure is, very similar to the carbon monoxide-liganded form with subtle differences, in ligand binding geometry. Oxygen binds to the heme iron in a bent, conformation with Fe-O-O angles of 135 degrees and 150 degrees for the two, subunits. These observed angles are lower than the equivalent angles in, the carbon monoxide-liganded form and intermediate between the angles, observed in structures of oxygenated sperm whale myoglobin and oxygenated, human hemoglobin. This third high resolution structure of Scapharca, dimeric hemoglobin permits a detailed analysis of the water structure in, the highly hydrated interface between subunits.
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<StructureSection load='1hbi' size='340' side='right'caption='[[1hbi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hbi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anadara_inaequivalvis Anadara inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HBI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hbi OCA], [https://pdbe.org/1hbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hbi RCSB], [https://www.ebi.ac.uk/pdbsum/1hbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hbi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLB1_ANAIN GLB1_ANAIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/1hbi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hbi ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1HBI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis] with HEM and OXY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HBI OCA].
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of oxygenated Scapharca dimeric hemoglobin at 1.7-A resolution., Condon PJ, Royer WE Jr, J Biol Chem. 1994 Oct 14;269(41):25259-67. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7929217 7929217]
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[[Category: Anadara inaequivalvis]]
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[[Category: Scapharca inaequivalvis]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Condon PJ]]
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[[Category: Condon, P.J.]]
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[[Category: Royer Junior WE]]
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[[Category: Junior, W.E.Royer.]]
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[[Category: HEM]]
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[[Category: OXY]]
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[[Category: oxygen transport]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov 8 13:04:20 2007''
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Current revision

CRYSTAL STRUCTURE OF OXYGENATED SCAPHARCA DIMERIC HEMOGLOBIN AT 1.7 ANGSTROMS RESOLUTION

PDB ID 1hbi

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