6qpc

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<SX load='6qpc' size='340' side='right' viewer='molstar' caption='[[6qpc]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<SX load='6qpc' size='340' side='right' viewer='molstar' caption='[[6qpc]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6qpc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6qpc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QPC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=P1O:1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>P1O</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ano6, Tmem16f ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=P1O:1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>P1O</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpc OCA], [http://pdbe.org/6qpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpc RCSB], [http://www.ebi.ac.uk/pdbsum/6qpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpc OCA], [https://pdbe.org/6qpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qpc RCSB], [https://www.ebi.ac.uk/pdbsum/6qpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ANO6_MOUSE ANO6_MOUSE]] Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.<ref>PMID:21107324</ref> <ref>PMID:21908539</ref> <ref>PMID:22936354</ref> <ref>PMID:23021219</ref> <ref>PMID:23532839</ref>
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[https://www.uniprot.org/uniprot/ANO6_MOUSE ANO6_MOUSE] Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.<ref>PMID:21107324</ref> <ref>PMID:21908539</ref> <ref>PMID:22936354</ref> <ref>PMID:23021219</ref> <ref>PMID:23532839</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6qpc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6qpc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Anoctamin 3D structures|Anoctamin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</SX>
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Alvadia, C]]
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[[Category: Alvadia C]]
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[[Category: Dutzler, R]]
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[[Category: Clerico Mosina V]]
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[[Category: Lim, N K]]
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[[Category: Dutzler R]]
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[[Category: Mosina, V Clerico]]
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[[Category: Lim NK]]
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[[Category: Oostergetel, G T]]
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[[Category: Oostergetel GT]]
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[[Category: Paulino, C]]
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[[Category: Paulino C]]
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[[Category: Lipid scramble]]
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[[Category: Membrane protein]]
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[[Category: Tmem16]]
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Current revision

Cryo-EM structure of calcium-bound mTMEM16F lipid scramblase in nanodisc

6qpc, resolution 3.50Å

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