6qpw

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<SX load='6qpw' size='340' side='right' viewer='molstar' caption='[[6qpw]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<SX load='6qpw' size='340' side='right' viewer='molstar' caption='[[6qpw]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QPW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTHT_0066330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD]), MCD1, PDS3, RHC21, SCC1, YDL003W, YD8119.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), SMC3, YJL074C, J1049 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), CTHT_0066330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpw OCA], [http://pdbe.org/6qpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpw RCSB], [http://www.ebi.ac.uk/pdbsum/6qpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpw OCA], [https://pdbe.org/6qpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qpw RCSB], [https://www.ebi.ac.uk/pdbsum/6qpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SCC1_YEAST SCC1_YEAST]] Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.<ref>PMID:9335333</ref> <ref>PMID:9335334</ref> <ref>PMID:9491073</ref> <ref>PMID:10403247</ref> [[http://www.uniprot.org/uniprot/SMC3_YEAST SMC3_YEAST]] Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
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[https://www.uniprot.org/uniprot/G0SGH3_CHATD G0SGH3_CHATD]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Baker's yeast]]
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[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
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[[Category: Chatd]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li, Y]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Muir, K W]]
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[[Category: Li Y]]
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[[Category: Panne, D]]
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[[Category: Muir KW]]
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[[Category: Weis, F]]
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[[Category: Panne D]]
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[[Category: Cell cycle]]
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[[Category: Weis F]]
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[[Category: Chromatin]]
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[[Category: Cohesin]]
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[[Category: Genome segregation]]
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Current revision

Structural basis of cohesin ring opening

6qpw, resolution 3.30Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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