6swy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:52, 14 July 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 3: Line 3:
<SX load='6swy' size='340' side='right' viewer='molstar' caption='[[6swy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<SX load='6swy' size='340' side='right' viewer='molstar' caption='[[6swy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6swy]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SWY FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6swy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SWY FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6swy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6swy OCA], [http://pdbe.org/6swy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6swy RCSB], [http://www.ebi.ac.uk/pdbsum/6swy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6swy ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6swy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6swy OCA], [https://pdbe.org/6swy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6swy RCSB], [https://www.ebi.ac.uk/pdbsum/6swy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6swy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/GID4_YEAST GID4_YEAST]] Substrate-recognition component of the GID complex, a multisubunit ubiquitin ligase that targets enzymes involved in gluconeogenesis for proteasomal degradation when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:18508925, PubMed:28126757). Specific for substrates with an N-terminal Pro (Pro/N-degron), including FBP1, ICL1 and MDH2 (PubMed:28126757). Has high affinity for the N-terminal sequence Pro-Thr-Leu-Val, and can bind peptides with an N-terminal sequence of the type Pro-[Gly,Ala,Ser,Thr,Asp,Asn,Tyr,His]-[Ala,Val,Leu,Ile,Lys,Arg]-[Val,Cys,Pro,Leu,Ile,Trp] (PubMed:28126757). Required for vacuolar degradation of FBP1 when cells are shifted to glucose-containing medium, probably by targeting FBP1-containing vesicles to the vacuole, but is not required for FBP1 sequestration in cytoplasmic vesicles (PubMed:9508768).<ref>PMID:12686616</ref> <ref>PMID:18508925</ref> <ref>PMID:28126757</ref> <ref>PMID:9508768</ref> [[http://www.uniprot.org/uniprot/VID28_YEAST VID28_YEAST]] Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616).<ref>PMID:12686616</ref> [[http://www.uniprot.org/uniprot/VID30_YEAST VID30_YEAST]] Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:9737955, PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:9737955, PubMed:12686616, PubMed:22645139, PubMed:28126757).<ref>PMID:12686616</ref> <ref>PMID:22645139</ref> <ref>PMID:28126757</ref> <ref>PMID:9737955</ref> [[http://www.uniprot.org/uniprot/GID8_YEAST GID8_YEAST]] Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616). Required also for cell cycle progression. Positively controls G1 and the timing of START (PubMed:15590836).<ref>PMID:12686616</ref> <ref>PMID:15590836</ref> [[http://www.uniprot.org/uniprot/FYV10_YEAST FYV10_YEAST]] Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:22044534). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616, PubMed:22044534). May catalyze ubiquitination of target proteins in complex with RMD5 (Probable). Required for survival upon exposure to K1 killer toxin (PubMed:12663529).<ref>PMID:12663529</ref> <ref>PMID:12686616</ref> <ref>PMID:22044534</ref>
+
[https://www.uniprot.org/uniprot/VID28_YEAST VID28_YEAST] Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616).<ref>PMID:12686616</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 23:
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Prabu, J R]]
+
[[Category: Saccharomyces cerevisiae S288C]]
-
[[Category: Qiao, S]]
+
[[Category: Prabu JR]]
-
[[Category: Schulman, B A]]
+
[[Category: Qiao S]]
-
[[Category: Ligase]]
+
[[Category: Schulman BA]]
-
[[Category: Suppreseed]]
+
-
[[Category: Suppressed]]
+

Current revision

Structure of active GID E3 ubiquitin ligase complex minus Gid2 and delta Gid9 RING domain

6swy, resolution 3.20Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6swy"
Personal tools