5r4y

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(New page: '''Unreleased structure''' The entry 5r4y is ON HOLD Authors: Talon, R., Krojer, T., Fairhead, M., Sethi, R., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A., W...)
Current revision (11:35, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5r4y is ON HOLD
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==XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13612a==
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<StructureSection load='5r4y' size='340' side='right'caption='[[5r4y]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5r4y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5R4Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GX4:cyclopropyl-[4-(4-fluorophenyl)piperazin-1-yl]methanone'>GX4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5r4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4y OCA], [https://pdbe.org/5r4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5r4y RCSB], [https://www.ebi.ac.uk/pdbsum/5r4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
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Authors: Talon, R., Krojer, T., Fairhead, M., Sethi, R., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A., Wright, N., MacLean, E., Renjie, Z., Dias, A., Brennan, P.E., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
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==See Also==
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*[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]]
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Description: XChem fragment screen --CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13612a
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Aimon, A]]
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__TOC__
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[[Category: Collins, P]]
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</StructureSection>
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[[Category: Arrowsmith, C.H]]
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[[Category: Homo sapiens]]
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[[Category: Brandao-Neto, J]]
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[[Category: Large Structures]]
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[[Category: Fairhead, M]]
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[[Category: Aimon A]]
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[[Category: Von Delft, F]]
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[[Category: Arrowsmith CH]]
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[[Category: Renjie, Z]]
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[[Category: Bountra C]]
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[[Category: Wright, N]]
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[[Category: Bradley AR]]
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[[Category: Bradley, A.R]]
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[[Category: Brandao-Neto J]]
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[[Category: Talon, R]]
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[[Category: Brennan PE]]
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[[Category: Brennan, P.E]]
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[[Category: Collins P]]
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[[Category: Edwards, A]]
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[[Category: Dias A]]
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[[Category: Maclean, E]]
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[[Category: Douangamath A]]
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[[Category: Douangamath, A]]
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[[Category: Edwards A]]
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[[Category: Krojer, T]]
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[[Category: Fairhead M]]
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[[Category: Dias, A]]
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[[Category: Krojer T]]
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[[Category: Sethi, R]]
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[[Category: MacLean E]]
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[[Category: Bountra, C]]
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[[Category: Sethi R]]
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[[Category: Talon R]]
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[[Category: Wright N]]
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[[Category: Zhang R]]
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[[Category: Von Delft F]]

Current revision

XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13612a

PDB ID 5r4y

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