6vqw

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<StructureSection load='6vqw' size='340' side='right'caption='[[6vqw]], [[Resolution|resolution]] 3.42&Aring;' scene=''>
<StructureSection load='6vqw' size='340' side='right'caption='[[6vqw]], [[Resolution|resolution]] 3.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6vqw]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VQW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VQW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6vqw]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VQW FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vqw OCA], [http://pdbe.org/6vqw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vqw RCSB], [http://www.ebi.ac.uk/pdbsum/6vqw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vqw ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.42&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vqw OCA], [https://pdbe.org/6vqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vqw RCSB], [https://www.ebi.ac.uk/pdbsum/6vqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vqw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CAS6_PSEAB CAS6_PSEAB]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units. Absolutely required for crRNA production or stability. Upon expression in E.coli endonucleolytically processes pre-crRNA, although disruption and reconstitution experiments indicate that in situ other genes are also required for processing. Yields 5'-hydroxy and 3'-phosphate groups. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.<ref>PMID:20829488</ref> <ref>PMID:21398535</ref> <ref>PMID:22522703</ref> [[http://www.uniprot.org/uniprot/CSY1_PSEAB CSY1_PSEAB]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential). Involved in crRNA production or stability. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.<ref>PMID:21398535</ref> <ref>PMID:22522703</ref>
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[https://www.uniprot.org/uniprot/CSY1_PSEAB CSY1_PSEAB] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential). Involved in crRNA production or stability. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.<ref>PMID:21398535</ref> <ref>PMID:22522703</ref>
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==See Also==
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chiu, W]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Huang, Z]]
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[[Category: Chiu W]]
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[[Category: Li, S]]
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[[Category: Huang Z]]
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[[Category: Pintilie, G]]
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[[Category: Li S]]
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[[Category: Zhang, K]]
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[[Category: Pintilie G]]
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[[Category: Zhu, Y]]
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[[Category: Zhang K]]
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[[Category: Acrf8]]
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[[Category: Zhu Y]]
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[[Category: Anti-crispr]]
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[[Category: Crispr]]
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[[Category: Csy]]
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[[Category: Rna binding protein-rna-inhibitor complex]]
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[[Category: Type i-f]]
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Current revision

Type I-F CRISPR-Csy complex with its inhibitor AcrF8

PDB ID 6vqw

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