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| | <StructureSection load='5b7w' size='340' side='right'caption='[[5b7w]], [[Resolution|resolution]] 2.08Å' scene=''> | | <StructureSection load='5b7w' size='340' side='right'caption='[[5b7w]], [[Resolution|resolution]] 2.08Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5b7w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanc8 Xanc8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B7W FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5b7w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris_str._8004 Xanthomonas campestris pv. campestris str. 8004]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B7W FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XC_3703 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=314565 XANC8])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b7w OCA], [http://pdbe.org/5b7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b7w RCSB], [http://www.ebi.ac.uk/pdbsum/5b7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b7w ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b7w OCA], [https://pdbe.org/5b7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b7w RCSB], [https://www.ebi.ac.uk/pdbsum/5b7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b7w ProSAT]</span></td></tr> |
| | </table> | | </table> |
| - | <div style="background-color:#fffaf0;">
| + | == Function == |
| - | == Publication Abstract from PubMed == | + | [https://www.uniprot.org/uniprot/Y3703_XANC8 Y3703_XANC8] |
| - | As an important bacterial second messenger, bis-(3',5')-cyclic diguanylate (cyclic di-GMP or c-di-GMP) has been implicated in numerous biological activities, including biofilm formation, motility, survival and virulence. These processes are manipulated by the binding of c-di-GMP to its receptors. XC_3703 from the plant pathogen Xanthomonas campestris pv. campestris, which belongs to the YajQ family of proteins, has recently been identified as a potential c-di-GMP receptor. XC_3703, together with XC_2801, functions as a transcription factor activating virulence-related genes, which can be reversed by the binding of c-di-GMP to XC_3703. However, the structural basis of how c-di-GMP regulates XC_3703 remains elusive. In this study, the structure of XC_3703 was determined to 2.1 A resolution using the molecular-replacement method. The structure of XC_3703 consists of two domains adopting the same topology, which is similar to that of the RNA-recognition motif (RRM). Arg65, which is conserved among the c-di-GMP-binding subfamily of the YajQ family of proteins, together with Phe80 in domain II, forms a putative c-di-GMP binding site.
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| - | Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv. campestris.,Zhao Z, Wu Z, Zhang J Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):720-5. doi:, 10.1107/S2053230X16013017. Epub 2016 Aug 26. PMID:27599864<ref>PMID:27599864</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | <div class="pdbe-citations 5b7w" style="background-color:#fffaf0;"></div>
| + | |
| - | == References ==
| + | |
| - | <references/>
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Xanc8]] | + | [[Category: Xanthomonas campestris pv. campestris str. 8004]] |
| - | [[Category: Wu, Z]] | + | [[Category: Wu Z]] |
| - | [[Category: Zhao, Z]] | + | [[Category: Zhao Z]] |
| - | [[Category: Receptor]]
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| - | [[Category: Unknown function]]
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