5bpv

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<StructureSection load='5bpv' size='340' side='right'caption='[[5bpv]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='5bpv' size='340' side='right'caption='[[5bpv]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5bpv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Zebov Zebov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5bpv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP35 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186538 ZEBOV])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.952&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpv OCA], [http://pdbe.org/5bpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpv RCSB], [http://www.ebi.ac.uk/pdbsum/5bpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpv OCA], [https://pdbe.org/5bpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpv RCSB], [https://www.ebi.ac.uk/pdbsum/5bpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VP35_EBOZ5 VP35_EBOZ5]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
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[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Zebov]]
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[[Category: Zaire ebolavirus]]
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[[Category: Alcaro, S]]
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[[Category: Alcaro S]]
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[[Category: Bianco, G]]
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[[Category: Bianco G]]
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[[Category: Cannas, V]]
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[[Category: Cannas V]]
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[[Category: Corona, A]]
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[[Category: Corona A]]
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[[Category: Daino, G L]]
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[[Category: Daino GL]]
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[[Category: Distinto, S]]
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[[Category: Distinto S]]
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[[Category: Esposito, F]]
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[[Category: Esposito F]]
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[[Category: Fadda, V]]
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[[Category: Fadda V]]
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[[Category: Maccioni, E]]
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[[Category: Maccioni E]]
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[[Category: Taylor, G L]]
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[[Category: Taylor GL]]
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[[Category: Tramontano, E]]
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[[Category: Tramontano E]]
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[[Category: Zinzula, L]]
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[[Category: Zinzula L]]
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[[Category: Interferon inhibitor]]
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[[Category: Polymerase cofactor]]
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[[Category: Viral protein]]
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Current revision

Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A

PDB ID 5bpv

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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