Tubulin tyrosine ligase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<scene name='70/707399/Cv/5'>Tubulin tyrosine ligase complex with α-tubulin (2 chains), β-tubulin (2 chains), and stathmin</scene>. TTL structure is composed of <scene name='70/707399/Cv/6'>N-terminal, central and C-terminal domains</scene>. <scene name='70/707399/Cv/7'>TTL interacts with α- and β-tubulin</scene> via 3 loops and one helix terminal<ref>PMID:23358242</ref>. | <scene name='70/707399/Cv/5'>Tubulin tyrosine ligase complex with α-tubulin (2 chains), β-tubulin (2 chains), and stathmin</scene>. TTL structure is composed of <scene name='70/707399/Cv/6'>N-terminal, central and C-terminal domains</scene>. <scene name='70/707399/Cv/7'>TTL interacts with α- and β-tubulin</scene> via 3 loops and one helix terminal<ref>PMID:23358242</ref>. | ||
| - | </StructureSection> | ||
== 3D Structures of tubulin tyrosine ligase == | == 3D Structures of tubulin tyrosine ligase == | ||
| - | + | [[Tubulin tyrosine ligase 3D structures]] | |
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| - | *Tubulin tyrosine ligase | ||
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| - | **[[3tig]] – fTTL - frog<br /> | ||
| - | **[[3tii]] – fTTL + ATP derivative <br /> | ||
| - | **[[3tin]] – fTTL + ADP <br /> | ||
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| - | *Tubulin tyrosine ligase complex with tubulin | ||
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| - | **[[5jqg]], [[5xp3]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative - pig <br /> | ||
| - | **[[4iij]] – cTTL + rSTM + tubulin + GTP + GDP - chicken<br /> | ||
| - | **[[4ihj]] – cTTL + rSTM + tubulin + GTP + GDP + ADP <br /> | ||
| - | **[[6i5c]], [[4i55]], [[6s9e]], [[6gze]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative <br /> | ||
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| - | *Tubulin tyrosine ligase complex with tubulin and inhibitor | ||
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| - | **[[5iyz]], [[5j2t]], [[5j2u]], [[5la6]], [[5bmv]], [[5jh7]] – bTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor - bovine<br /> | ||
| - | **[[4zhq]], [[4zi7]], [[4zol]], [[5c8y]], [[5fnv]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5lov]], [[5lyj]], [[5m7e]], [[5njh]], [[5lxs]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor <br /> | ||
| - | **[[5iyz]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + auristatin <br /> | ||
| - | **[[5cb4]] – bpTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor – bearded pig<br /> | ||
| - | **[[5xkf]], [[5xkg]] – cTTL + rSTM + tubulin + GTP + GDP + inhibitor<br /> | ||
| - | **[[4o2a]], [[5fnv]], [[5ca1]] – cTTL + rSTM + tubulin + GTP + GDP + ADP + inhibitor<br /> | ||
| - | **[[5ng1]], [[5nfz]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + stabilizer <br /> | ||
| - | **[[4o4l]], [[4tuy]], [[4tv8]], [[4yj2]], [[4yj3]], [[5j2t]], [[5xiw]] – cTTL + rSTM + tubulin + GTP + GDP + anti-cancer drugs<br /> | ||
| - | **[[4o4h]], [[4o4j]], [[4o4i]], [[5c8y]], [[5cb4]], [[5ca1]], [[5bmv]], [[5jh7]], [[5lxt]], [[4i4t]], [[5osk]], [[5xlt]], [[5xlz]], [[5mw1]], [[6fii]], [[6fjm]], [[5xag]], [[4i50]], [[6knz]], [[6gj4]], [[6gf3]], [[6f7c]], [[5yl4]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-cancer drug<br /> | ||
| - | **[[6qqn]], [[6k9v]], [[6jcj]], [[6hx8]], [[6eg5]], [[6agk]], [[5zxh]], [[5z4u]], [[5z4p]], [[5yz3]], [[5h7o]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor<br /> | ||
| - | **[[6o61]], [[6o5n]], [[6o5m]], [[6nng]] – cTTL + hSTM + tubulin + GTP + GDP + ATP derivative + inhibitor<br /> | ||
| - | **[[5jcb]] – cTTL + pSTM + tubulin + GTP + GDP + ATP derivative + anti-cancer drug<br /> | ||
| - | **[[4o2b]], [[5lp6]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-gout drug<br /> | ||
| - | **[[5yl2]], [[5ylj]], [[5yls]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fjf]], [[6fkj]], [[6fkl]], [[5xhc]], [[5xi5]], [[5xi7]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor<br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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