Inosine monophosphate dehydrogenase 3D structures

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Current revision (08:29, 29 May 2023) (edit) (undo)
 
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Line 9: Line 9:
**[[1eep]] – IMPDH – ''Borellia burgdorferi'' <br />
**[[1eep]] – IMPDH – ''Borellia burgdorferi'' <br />
**[[1zfj]] – IMPDH catalytic domain – ''Streptococcus pyogenes'' <br />
**[[1zfj]] – IMPDH catalytic domain – ''Streptococcus pyogenes'' <br />
 +
**[[7xlo]] – IMPDH catalytic domain 1-97, 208-496 – ''Methanocaldococcus jannaschii'' <br />
**[[1vrd]] – IMPDH – ''Thermotoga maritima'' <br />
**[[1vrd]] – IMPDH – ''Thermotoga maritima'' <br />
**[[3ffs]] – CpIMPDH – ''Cryptosporidium parvum''<br />
**[[3ffs]] – CpIMPDH – ''Cryptosporidium parvum''<br />
Line 22: Line 23:
**[[1jcn]] – hMPDH 1 + IMP derivative - human<br />
**[[1jcn]] – hMPDH 1 + IMP derivative - human<br />
 +
**[[6udp]] – hMPDH 2 + IMP – Cryo EM <br />
**[[1jr1]] – hMPDH 2 + mycophenolic acid <br />
**[[1jr1]] – hMPDH 2 + mycophenolic acid <br />
**[[6i0m]] – hMPDH 2 + GDP<br />
**[[6i0m]] – hMPDH 2 + GDP<br />
Line 27: Line 29:
**[[1me8]] – TfIMPDH + ribavirin monophosphate <br />
**[[1me8]] – TfIMPDH + ribavirin monophosphate <br />
**[[1pvn]] – TfIMPDH catalytic domain + transition state analog <br />
**[[1pvn]] – TfIMPDH catalytic domain + transition state analog <br />
-
**[[1me9]] – TfIMPDH + inosinic acid <br />
+
**[[1me9]] – TfIMPDH + IMP <br />
**[[2cu0]] – IMPDH + xanthosine monophosphate – ''Pyrococcus horikoshii''<br />
**[[2cu0]] – IMPDH + xanthosine monophosphate – ''Pyrococcus horikoshii''<br />
**[[5upx]] – LmIMPDH + xanthosine monophosphate – ''Listeria monocytogenes''<br />
**[[5upx]] – LmIMPDH + xanthosine monophosphate – ''Listeria monocytogenes''<br />
-
**[[3usb]] – BaIMPDH + inosinic acid <br />
+
**[[8ebc]] – LmIMPDH + IMP <br />
 +
**[[3usb]] – BaIMPDH + IMP <br />
**[[6mgu]] – BaIMPDH + oxaosine monophosphate <br />
**[[6mgu]] – BaIMPDH + oxaosine monophosphate <br />
**[[3tsd]] – BaIMPDH (mutant) + xanthosine monophosphate <br />
**[[3tsd]] – BaIMPDH (mutant) + xanthosine monophosphate <br />
-
**[[4ix2]] – VcIMPDH + inosinic acid <br />
+
**[[4ix2]] – VcIMPDH + IMP <br />
**[[4qq3]] – VcIMPDH (mutant) + XMP <br />
**[[4qq3]] – VcIMPDH (mutant) + XMP <br />
**[[4dqw]] – PaIMPDH + ATP <br />
**[[4dqw]] – PaIMPDH + ATP <br />
**[[6gk9]] – PaIMPDH + inhibitor <br />
**[[6gk9]] – PaIMPDH + inhibitor <br />
-
**[[5ahm]], [[5ahn]] – PaIMPDH (mutant) + inosinic acid <br />
+
**[[5ahm]], [[5ahn]] – PaIMPDH (mutant) + IMP <br />
**[[6mgr]] – CjIMPDH catalytic domain + oxanosin monophosphate – ''Campylobacter jejuni''<br />
**[[6mgr]] – CjIMPDH catalytic domain + oxanosin monophosphate – ''Campylobacter jejuni''<br />
-
**[[4r7j]] – CjIMPDH catalytic domain (mutant) + inosinic acid <br />
+
**[[4r7j]] – CjIMPDH catalytic domain (mutant) + IMP <br />
**[[5uqh]], [[5uqf]], [[5uqg]] – CjIMPDH catalytic domain (mutant) + inhibitor<br />
**[[5uqh]], [[5uqf]], [[5uqg]] – CjIMPDH catalytic domain (mutant) + inhibitor<br />
-
**[[4xtd]], [[4xti]] – AgIMPDH (mutant) + inosinic acid <br />
+
**[[4xtd]], [[4xti]] – AgIMPDH (mutant) + IMP <br />
**[[4z0g]] – AgIMPDH (mutant) + GMP <br />
**[[4z0g]] – AgIMPDH (mutant) + GMP <br />
**[[5mcp]] – AgIMPDH + ATP <br />
**[[5mcp]] – AgIMPDH + ATP <br />
-
**[[6d4q]], [[6d4r]], [[6d4s]], [[6d4t]], [[6d4u]], [[6d4v]], [[6d4w]] – IMPDH + inhibitor – ''Mycobacterium thermoresistibile''<br />
+
**[[6d4q]], [[6d4r]], [[6d4s]], [[6d4t]], [[6d4u]], [[6d4v]], [[6d4w]], [[6mjy]] – IMPDH + inhibitor – ''Mycobacterium thermoresistibile''<br />
-
**[[6lk4]] – IMPDH + GTP – ''Trypanosoma brucei''<br />
+
**[[6lk4]] – TbIMPDH + GTP – ''Trypanosoma brucei''<br />
-
*IMPDH ternary complex with inosinic acid and inhibitor
+
*IMPDH ternary complex with inosinic acid (IMP) and inhibitor
**[[1b3o]] – hMPDH 2 + selenazole inhibitor + IMP derivative <br />
**[[1b3o]] – hMPDH 2 + selenazole inhibitor + IMP derivative <br />
-
**[[4ixh]], [[3khj]], [[4qj1]] – CpIMPDH catalytic domain + inhibitor + inosinic acid <br />
+
**[[4ixh]], [[3khj]], [[4qj1]] – CpIMPDH catalytic domain + inhibitor + IMP <br />
-
**[[4rv8]] - CpIMPDH catalytic domain (mutant) + inhibitor + inosinic acid <br />
+
**[[4rv8]] – CpMPDH (mutant) + IMP + inhibitor <br />
-
**[[4zqn]], [[4zqo]], [[4zqp]], [[4zqr]], [[5upu]], [[5ou1]], [[5ou2]], [[5ou3]] - MtIMPDH catalytic domain + inhibitor + inosinic acid <br />
+
**[[4zqn]], [[4zqo]], [[4zqp]], [[4zqr]], [[5upu]], [[5ou1]], [[5ou2]], [[5ou3]] - MtIMPDH catalytic domain + inhibitor + IMP <br />
-
**[[5upv]] - MtIMPDH catalytic domain (mutant) + inhibitor + inosinic acid <br />
+
**[[5upv]] - MtIMPDH catalytic domain (mutant) + inhibitor + IMP <br />
-
**[[5j5r]], [[5k4x]], [[5k4z]] - MrIMPDH + inhibitor + inosinic acid – ''Mycobacterium thermoresistibile''<br />
+
**[[5j5r]], [[5k4x]], [[5k4z]] - MrIMPDH + inhibitor + IMP – ''Mycobacterium thermoresistibile''<br />
-
**[[5urr]], [[5urs]], [[5uuv]], [[5uuw]], [[5uuz]] – BaIMPDH catalytic domain + inhibitor + inosinic acid <br />
+
**[[7mtx]], [[5urs]], [[5uuv]], [[7mtu]], [[5uuz]], [[7mtu]], [[7mtx]] – BaIMPDH catalytic domain + inhibitor + IMP <br />
-
**[[4my1]], [[4mya]], [[4my8]], [[4my9]], [[4qm1]] – BaIMPDH catalytic domain (mutant) + inhibitor + inosinic acid <br />
+
**[[4my1]], [[4mya]], [[4my8]], [[4my9]], [[4qm1]] – BaIMPDH catalytic domain (mutant) + inhibitor + IMP <br />
-
**[[4mz1]], [[4mz8]] – CjIMPDH catalytic domain (mutant) + inhibitor + inosinic acid <br />
+
**[[4mz1]], [[4mz8]] – CjIMPDH catalytic domain (mutant) + inhibitor + IMP <br />
-
**[[5urq]] – CjIMPDH catalytic domain + inhibitor + inosinic acid <br />
+
**[[5urq]] – CjIMPDH catalytic domain + inhibitor + IMP <br />
-
**[[4q32]], [[4q33]] – MPDH + IMP + inhibitor – ''Clostridium perfringens'' <br />
+
**[[4q32]], [[4q33]] – ClpMPDH + IMP + inhibitor – ''Clostridium perfringens'' <br />
-
**[[5uwx]]]], [[5uxe]], [[5uzc]], [[5uze]], [[5uzs]], [[5vsv]] – CpMPDH (mutant) + IMP + inhibitor – ''Clostridium perfringens'' <br />
+
**[[5uwx]]]], [[5uxe]], [[5uzc]], [[5uze]], [[5uzs]], [[5vsv]] – ClpMPDH (mutant) + IMP + inhibitor <br />
-
**[[4af0]] – IMPDH + mycophenolic acid + inosinic acid – ''Cryptococcus neoformans''<br />
+
**[[4af0]] – IMPDH + mycophenolic acid + IMP – ''Cryptococcus neoformans''<br />
-
**[[5upy]] - LmIMPDH catalytic domain + inhibitor + inosinic acid <br />
+
**[[5upy]] - LmIMPDH catalytic domain + inhibitor + IMP <br />
*IMPDH other ternary complexes
*IMPDH other ternary complexes
 +
**[[6u8e]], [[6u8s]], [[6ua5]] – hMPDH 2 + NAD + IMP – Cryo EM <br />
 +
**[[6u8n]], [[6u8r]] – hMPDH 2 + NAD + ATP + IMP – Cryo EM <br />
 +
**[[6uc2]] – hMPDH 2 + ATP + GTP – Cryo EM <br />
 +
**[[6udo]], [[6udq]] – hMPDH 2 + ATP + GTP + IMP – Cryo EM <br />
 +
**[[6u9o]], [[6ua2]], [[6ua4]], [[6uaj]] – hMPDH 2 + NAD + ATP + GTP + IMP – Cryo EM <br />
**[[1nfb]] – hMPDH 2 + NAD + IMP derivative <br />
**[[1nfb]] – hMPDH 2 + NAD + IMP derivative <br />
**[[1nf7]] – hMPDH 2 + mycophenolic adenine dinucleotide + ribavirin monophosphate <br />
**[[1nf7]] – hMPDH 2 + mycophenolic adenine dinucleotide + ribavirin monophosphate <br />
**[[1me7]] – TfIMPDH + ribavirin monophosphate + mycophenolic acid <br />
**[[1me7]] – TfIMPDH + ribavirin monophosphate + mycophenolic acid <br />
-
**[[1lrt]] – TfIMPDH + adenine derivative + inosinic acid <br />
+
**[[1lrt]] – TfIMPDH + adenine derivative + IMP <br />
-
**[[1meh]] – TfIMPDH + mycophenolic acid + inosinic acid <br />
+
**[[1meh]] – TfIMPDH + mycophenolic acid + IMP <br />
**[[1mei]] – TfIMPDH + mycophenolic acid + xanthosine monophosphate <br />
**[[1mei]] – TfIMPDH + mycophenolic acid + xanthosine monophosphate <br />
**[[1mew]] – TfIMPDH + NAD + xanthosine monophosphate <br />
**[[1mew]] – TfIMPDH + NAD + xanthosine monophosphate <br />
**[[4zqm]] – MtIMPDH + NAD + xanthosine monophosphate – ''Mycobacterium tuberculosis''<br />
**[[4zqm]] – MtIMPDH + NAD + xanthosine monophosphate – ''Mycobacterium tuberculosis''<br />
-
**[[4fo4]], [[4fxs]] – VcIMPDH + mycophenolic acid + inosinic acid <br />
+
**[[4fo4]], [[4fxs]] – VcIMPDH + mycophenolic acid + IMP <br />
**[[4qne]] – VcIMPDH (mutant) + NAD + IMP <br />
**[[4qne]] – VcIMPDH (mutant) + NAD + IMP <br />
**[[4x3z]] – VcIMPDH (mutant) + NAD + XMP <br />
**[[4x3z]] – VcIMPDH (mutant) + NAD + XMP <br />
Line 80: Line 88:
**[[5tc3]] – AgIMPDH + ATP + GDP<br />
**[[5tc3]] – AgIMPDH + ATP + GDP<br />
**[[6rpu]] – AgIMPDH + AP5G + GDP<br />
**[[6rpu]] – AgIMPDH + AP5G + GDP<br />
 +
**[[6rfu]] – TbIMPDH + ATP + GMP<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of inosine monophosphate dehydrogenase

Updated on 29-May-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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