Urease accessory protein

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'''Urease accessory protein''' (Ure) is a Ni-containing urea hydrolase involved in nitrogen recycling from arginine, ureide and purines. Ure proteins are involved in urease activation by the transfer of Ni into the protein<ref>PMID:11289508</ref>.
'''Urease accessory protein''' (Ure) is a Ni-containing urea hydrolase involved in nitrogen recycling from arginine, ureide and purines. Ure proteins are involved in urease activation by the transfer of Ni into the protein<ref>PMID:11289508</ref>.
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*'''UreD''' - required for nickel incorporation <ref>PMID:12471450</ref>.<br />
*'''UreE''' - see [[Molecular Playground/UreE]].<br />
*'''UreE''' - see [[Molecular Playground/UreE]].<br />
*'''UreF''' - modulates the activation process of urease by eliminating the binding of Ni irons to noncarbamylated protein<ref>PMID:8808930</ref>.<br />
*'''UreF''' - modulates the activation process of urease by eliminating the binding of Ni irons to noncarbamylated protein<ref>PMID:8808930</ref>.<br />
*'''UreG''' - modulates the activation process of urease in plants <ref>PMID:28710280</ref>.<br />
*'''UreG''' - modulates the activation process of urease in plants <ref>PMID:28710280</ref>.<br />
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*'''UreH''' - forms in combination with UreF and UreG a pre-activation complex which activates urease<ref>PMID:22013070</ref>.<br />
*'''UreI''' - probably facilitates nickel incorporation.<br />
*'''UreI''' - probably facilitates nickel incorporation.<br />
== Structural highlights ==
== Structural highlights ==
The <scene name='59/590652/Cv/3'>Ni+2 ion coordinates ligands which include 3 His residues belonging to the two monomers, water molecule</scene><ref>PMID:22010876</ref>. Water molecule is shown as red sphere.
The <scene name='59/590652/Cv/3'>Ni+2 ion coordinates ligands which include 3 His residues belonging to the two monomers, water molecule</scene><ref>PMID:22010876</ref>. Water molecule is shown as red sphere.
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</StructureSection>
 
==3D structures of urease accessory protein==
==3D structures of urease accessory protein==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Urease accessory protein 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Urease accessory protein E
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**[[1gmv]], [[1gmu]] – KaUreE residues 1-143 (mutant) – ''Klebsiella aerogenes''<br />
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**[[1gmw]] – KaUreE residues 1-143 (mutant) + Cu <br />
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**[[4l3k]] – UreE + Zn + Ni – ''Sporosarcina pasteurii''<br />
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**[[3tj8]], [[3ny0]] – HpUreE + Ni – ''Helicobacter pylori''<br />
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**[[3tj9]] – HpUreE + Zn<br />
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**[[3nxz]] – HpUreE + Cu<br />
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**[[3la0]] – HpUreE + metal<br />
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**[[3tja]], [[3l9z]] – HpUreE <br />
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**[[1ear]], [[1eb0]] – UreE (mutant) + Zn – ''Bacillus pasteurii''<br />
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*Urease accessory protein F
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**[[2wgl]], [[3cxn]], [[3o1q]] – HpUreF <br />
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**[[3sf5]] – HpUreF + HpUreH<br />
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**[[4hi0]] – HpUreF + HpUreG + HpUreH<br />
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**[[6jc4]] – KpUreE – ''Klebsiella pnemoniae''<br />
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*Urease accessory protein G
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**[[5xkt]] – KpUreG + GMPPNP + Ni <br />
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*Urease accessory protein I
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**[[3ux4]] – HpUreI <br />
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}}
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Structure of UreE complex with formate and Ni+2 (PDB code 3tj8)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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