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==Coronavirus Disease 2019 (COVID-19)== | ==Coronavirus Disease 2019 (COVID-19)== | ||
<StructureSection load='6vsb' size='250' side='right' scene='83/839264/Covid-19_spike/1' caption='COVID-19 surface spike (PDB entry [[6vsb]])'> | <StructureSection load='6vsb' size='250' side='right' scene='83/839264/Covid-19_spike/1' caption='COVID-19 surface spike (PDB entry [[6vsb]])'> | ||
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| + | [[Image:Ezgif.com-Small crop.gif|left|230px|thumb|<span style="font-size:125%">Overall view of the COVID-19 virus. Note the spikes <span style="color:blue">blue</span> that adorn the outer surface,<span style="color:red">red</span>, which impart a '''corona''' like appearance. (Fusion Animation).</span>]]<br /> | ||
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A novel coronavirus was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. The illness caused by this virus has been named coronavirus disease 2019 (COVID-19). The illustration (left) shows the overall structure of the COVID-19 virus. Note the spikes that adorn the outer surface, colored <span style="color:red">red</span>, which impart the look of a '''corona''' surrounding the virus. A close up view of these spikes can be seen on the right, from studies by McLellan lab<ref name="McLellan">PMID:32075877</ref>. An animation (by [http://elarasystems.com Elara Systems)] shows how [http://www.dropbox.com/s/24e5f5wdh64f5fv/ES_NL_CoronaVirus_Final.mp4?dl=0 COVID-19 interacts with its host], via these spikes, thus permitting its genome to enter the host (human) cell<ref name="McLellan" />. | A novel coronavirus was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. The illness caused by this virus has been named coronavirus disease 2019 (COVID-19). The illustration (left) shows the overall structure of the COVID-19 virus. Note the spikes that adorn the outer surface, colored <span style="color:red">red</span>, which impart the look of a '''corona''' surrounding the virus. A close up view of these spikes can be seen on the right, from studies by McLellan lab<ref name="McLellan">PMID:32075877</ref>. An animation (by [http://elarasystems.com Elara Systems)] shows how [http://www.dropbox.com/s/24e5f5wdh64f5fv/ES_NL_CoronaVirus_Final.mp4?dl=0 COVID-19 interacts with its host], via these spikes, thus permitting its genome to enter the host (human) cell<ref name="McLellan" />. | ||
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== Potential treatments and ways to minimize exposure to COVID-19 == | == Potential treatments and ways to minimize exposure to COVID-19 == | ||
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'''Nature's Vacuum Cleaner - Binding of ACh to AChE'''<br> | '''Nature's Vacuum Cleaner - Binding of ACh to AChE'''<br> | ||
Movie by Richard Gillilan, Israel Silman & Joel L. Sussman | Movie by Richard Gillilan, Israel Silman & Joel L. Sussman | ||
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| - | + | <html5media height=“360” width=“640”>https://www.youtube. | |
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* A USA, French UK study '''identified 69 drugs to test against the coronavirus'''<ref> Gordon, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing: bioRxiv (online) 2020 [http://doi.org/10.1101/2020.03.22.002386 http://doi.org/10.1101/2020.03.22.002386]</ref>. As reported in the [http://www.nytimes.com/2020/03/22/science/coronavirus-drugs-chloroquine.html?action=click&module=Top%20Stories&pgtype=Homepage New York Times] (23-Mar-2020) "The researchers sought drugs that also latch onto the human proteins that the coronavirus seems to need to enter and replicate in human cells." | * A USA, French UK study '''identified 69 drugs to test against the coronavirus'''<ref> Gordon, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing: bioRxiv (online) 2020 [http://doi.org/10.1101/2020.03.22.002386 http://doi.org/10.1101/2020.03.22.002386]</ref>. As reported in the [http://www.nytimes.com/2020/03/22/science/coronavirus-drugs-chloroquine.html?action=click&module=Top%20Stories&pgtype=Homepage New York Times] (23-Mar-2020) "The researchers sought drugs that also latch onto the human proteins that the coronavirus seems to need to enter and replicate in human cells." | ||
Current revision
Coronavirus Disease 2019 (COVID-19)
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References
- ↑ 1.0 1.1 1.2 Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020 Feb 19. pii: science.abb2507. doi: 10.1126/science.abb2507. PMID:32075877 doi:http://dx.doi.org/10.1126/science.abb2507
- ↑ Gordon, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing: bioRxiv (online) 2020 http://doi.org/10.1101/2020.03.22.002386
- ↑ Gautret, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open- label non-randomized clinical trial: Intl J Antimcrob Agents (in press) 2020 http://dx.doi.org/10.1016/j.ijantimicag.2020.105949
- ↑ Gao, et al. Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target: bioRxiv (online) 2020 https://doi.org/10.1101/2020.03.16.993386
- ↑ Jin, et al. Structure of Mpro from COVID-19 virus and discovery of its inhibitors: bioRxiv (online) 2020[1]
- ↑ Andersen, et al. The proximal origin of SARS-CoV-2: Nature Med (in press) 2020 http://dx.doi.org/10.1038/s41591-020-0820-9]
- ↑ Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. Science. 2020 Mar 4. pii: science.abb2762. doi: 10.1126/science.abb2762. PMID:32132184 doi:http://dx.doi.org/10.1126/science.abb2762
- ↑ Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther. 2020;14(1):58-60. doi: 10.5582/ddt.2020.01012. PMID:32147628 doi:http://dx.doi.org/10.5582/ddt.2020.01012
