Vascular Endothelial Growth Factor

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==Introduction==
==Introduction==
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[[Vascular Endothelial Growth Factor]]s (VEGFs) are a class of proteins that regulate vascular development in embryos and angiogenesis in adult mammals after sustaining an injury or notably in [[Cancer|cancerous]] tumors. A number of structural studies have been conducted on VEGF and its receptors (VEGFRs) to better understand the VEGF-VEGFR interaction and how the signal cascade originating from this interaction leads to a number of biological features. VEGF and its receptors have been closely looked at for their potential use as targets for pharmaceutical medicine with some success. The VEGF family contains VEGF-A which mediates increased vascular permeability, VEGF-B which is a growth factor, VEGF-C is active in angiogenesis, VEGF-E is found in viruses and VEGF-F in snake venom.<br /> For additional information see:<br />
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[[Vascular Endothelial Growth Factor]]s (VEGFs) are a class of proteins that regulate vascular development in embryos and angiogenesis in adult mammals after sustaining an injury or notably in [[Cancer|cancerous]] tumors. A number of structural studies have been conducted on VEGF and its receptors (VEGFRs) to better understand the VEGF-VEGFR interaction and how the signal cascade originating from this interaction leads to a number of biological features. VEGF and its receptors have been closely looked at for their potential use as targets for pharmaceutical medicine with some success. The VEGF family contains:
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*'''VEGF-A''' which mediates increased vascular permeability<ref>PMID:33478167</ref>.
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*'''VEGF-B''' which is a growth factor <ref>PMID:19684473</ref>.
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*'''VEGF-C''' and '''VEGF-D''' are active in angiogenesis<ref>PMID:9708799</ref>,<ref>PMID:37686121</ref>.
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*'''VEGF-E''' is found in viruses<ref>PMID:22507661</ref>
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*'''VEGF-F''' found in snake venom<ref>PMID:15542594</ref>.<br />
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For additional information see:<br />
[[VEGFR]]<br />
[[VEGFR]]<br />
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[[VEGF IN COMPLEX WITH A NEUTRALIZING ANTIBODY]]..
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[[VEGF IN COMPLEX WITH A NEUTRALIZING ANTIBODY]]<br />
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[[Autocrine signaling]]<br />
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[[VEGF signaling pathway]].
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== 3D Structures of VEGF==
== 3D Structures of VEGF==
[[VEGF 3D Structures]]
[[VEGF 3D Structures]]
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</StructureSection>
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== 3D Structures of VEGF==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*VEGF-A; Domains - receptor-binding domain 27-135; heparin-binding domain 137-191
 
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**[[5hhc]], [[5hhd]] – hVEGF-A 214-315 - human <br />
 
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**[[1mkg]], [[1mkk]], [[1mjv]] – hVEGF-A receptor-binding domain (mutant) <br />
 
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**[[3bdy]], [[2qr0]] - hVEGF-A receptor-binding domain + hFab light+heavy chain <br />
 
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**[[4kzn]], [[3qtk]], [[2vpf]], [[1vpf]] - hVEGF-A receptor-binding domain<br />
 
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**[[2fjg]], [[2fjh]] - hVEGF-A receptor-binding domain + hFab light+heavy chain <br />
 
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**[[3p9w]] - hVEGF-A receptor-binding domain + hFab heavy chain<br />
 
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**[[5fv1]], [[5fv2]] – hVEGF-A receptor-binding domain + antibody residues 1-108<br />
 
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**[[4zff]], [[6bft]] - hVEGF-A residues 217-315 + hFab light+heavy chain<br />
 
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**[[1tzh]], [[1tzi]], [[1cz8]] - hVEGF-A receptor-binding domain + mFab YADS1 light+heavy chain - mouse<br />
 
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**[[5o4e]] – hVEGF-A receptor-binding domain (mutant) + IgG γ-1<br />
 
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**[[4glu]] - hVEGF-A receptor-binding domain<br />
 
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**[[1kmx]] - hVEGF-A heparin-binding domain<br />
 
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**[[1vgh]], [[2vgh]] - hVEGF-A heparin-binding domain - NMR<br />
 
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**[[1qty]], [[1flt]] – hVEGF-A receptor-binding domain + hFMS-like tyrosine <br />
 
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**[[1vpp]] – hVEGF-A receptor-binding domain + receptor blocking peptide <br />
 
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**[[6d3o]] – hVEGF-A receptor-binding domain + HH4 peptide <br />
 
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**[[1bj1]] – hVEGF-A receptor-binding domain + mFab light+heavy chain fragments <br />
 
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**[[1kat]] - hVEGF-A receptor binding domain + peptide antagonist - NMR<br />
 
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**[[3s1b]] - hVEGF-A receptor-binding domain + Mini-Z<br />
 
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**[[3s1k]] - hVEGF-A receptor-binding domain + Z-domain<br />
 
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**[[4gln]], [[4gls]] - hVEGF-A receptor-binding domain + D-RFX001<br />
 
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**[[4deq]] – hVEGF-A /neuropilin-1<br />
 
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**[[4qaf]] – hVEGF-A receptor-binding domain + lipocalin-1<br />
 
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**[[4wpb]] – hVEGF-A 214-315 + α/βVEGF<br />
 
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**[[5hhc]], [[5hhd]] – hVEGF-A heterochiral 214-315<br />
 
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**[[5t89]] – hVEGF-A receptor-binding domain+ VEGFR1 <br />
 
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*VEGF-B
 
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**[[2xac]] – hVEGF-B receptor binding domain+ hVEGFR domain 2<br />
 
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**[[2vwe]] – hVEGF-B + mFab light+heavy chain fragments <br />
 
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**[[2c7w]] – hVEGF-B <br />
 
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**[[3v2a]] – hVEGF-B + VEGF-A<br />
 
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*VEGF-C
 
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**[[2x1w]], [[2x1x]] – hVEGF-C VEGF homology domain+ VEGFR-2 domains 2 & 3<br />
 
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**[[4bsk]] - hVEGF-C VEGF homology domain + VEGFR-3 domains 1 & 2<br />
 
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*VEGF-D
 
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**[[2xv7]] – hVEGF-D VEGF homology domain
 
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*VEGF-E
 
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**[[2gnn]] – VEGF-E – Orf virus<br />
 
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**[[3v6b]] – VEGF-E + VEGFR 2 <br />
 
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*VEGF-F
 
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**[[1wq8]], [[1wq9]] - VEGF-F – ''Vipera aspis''
 
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}}
 
==Additional Resources==
==Additional Resources==
For additional information, see:
For additional information, see:
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==References==
==References==
<references />
<references />
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</StructureSection>
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of Human VEGF-A dimer, 1vpf

Drag the structure with the mouse to rotate
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