6lwt

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'''Unreleased structure'''
 
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The entry 6lwt is ON HOLD until Paper Publication
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==Crystal structure of Staphylococcal Superantigen-Like protein 10==
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<StructureSection load='6lwt' size='340' side='right'caption='[[6lwt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Nan, J., Chengliang, W., Tianrong, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6lwt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LWT FirstGlance]. <br>
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Description: Crystal structure of Staphylococcal Superantigen-Like protein 10
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lwt OCA], [https://pdbe.org/6lwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lwt RCSB], [https://www.ebi.ac.uk/pdbsum/6lwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lwt ProSAT]</span></td></tr>
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[[Category: Tianrong, H]]
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</table>
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[[Category: Chengliang, W]]
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== Function ==
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[[Category: Nan, J]]
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[https://www.uniprot.org/uniprot/SSL10_STAA8 SSL10_STAA8] Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction (PubMed:19913916). Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12. Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin (PubMed:23754290, PubMed:28193526). Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration (PubMed:19308288).<ref>PMID:19308288</ref> <ref>PMID:19913916</ref> <ref>PMID:23754290</ref> <ref>PMID:28193526</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Staphylococcus aureus]]
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[[Category: Chengliang W]]
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[[Category: Nan J]]
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[[Category: Tianrong H]]

Current revision

Crystal structure of Staphylococcal Superantigen-Like protein 10

PDB ID 6lwt

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