6w6r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==WT HTLV-1 Protease in Complex with UMass6 (UM6)== | |
| - | + | <StructureSection load='6w6r' size='340' side='right'caption='[[6w6r]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6w6r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W6R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A60:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL+[(1S,2R)-3-{[(4-AMINOPHENYL)SULFONYL](2-ETHYLBUTYL)AMINO}-1-BENZYL-2-HYDROXYPROPYL]CARBAMATE'>A60</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w6r OCA], [https://pdbe.org/6w6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w6r RCSB], [https://www.ebi.ac.uk/pdbsum/6w6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w6r ProSAT]</span></td></tr> |
| - | [[Category: Henes | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PRO_HTL1A PRO_HTL1A] Matrix protein p19 targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p15 is involved in the packaging and encapsidation of two copies of the genome. The aspartyl protease mediates proteolytic cleavages of Gag, Gag-Pro and Gag-Pro-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell. Hydrolyzes host EIF4GI in order to shut off the capped cellular mRNA translation. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response (By similarity). |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Nalivaika | + | </StructureSection> |
| - | [[Category: | + | [[Category: Human T-cell leukemia virus type I]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ali A]] | ||
| + | [[Category: Henes M]] | ||
| + | [[Category: Kosovrasti K]] | ||
| + | [[Category: KurtYilmaz N]] | ||
| + | [[Category: Lockbaum GJ]] | ||
| + | [[Category: Nalivaika EA]] | ||
| + | [[Category: Schiffer CA]] | ||
Current revision
WT HTLV-1 Protease in Complex with UMass6 (UM6)
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