6rpz

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Current revision (11:51, 1 February 2024) (edit) (undo)
 
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<StructureSection load='6rpz' size='340' side='right'caption='[[6rpz]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
<StructureSection load='6rpz' size='340' side='right'caption='[[6rpz]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rpz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RPZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rpz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RPZ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6rpx|6rpx]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rpz OCA], [http://pdbe.org/6rpz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rpz RCSB], [http://www.ebi.ac.uk/pdbsum/6rpz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rpz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rpz OCA], [https://pdbe.org/6rpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rpz RCSB], [https://www.ebi.ac.uk/pdbsum/6rpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rpz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CRLF3_MOUSE CRLF3_MOUSE]] May play a role in the negative regulation of cell cycle progression.
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[https://www.uniprot.org/uniprot/CRLF3_MOUSE CRLF3_MOUSE] May play a role in the negative regulation of cell cycle progression.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood platelet count. Proplatelet formation releases into the bloodstream beads-on-a-string preplatelets, which undergo fission into mature platelets. For the first time, we show that preplatelet maturation is a third, tightly regulated, critical process akin to cytokinesis that regulates platelet count. We show that deficiency in cytokine receptor-like factor 3 (CRLF3) in mice leads to an isolated and sustained 25% to 48% reduction in the platelet count without any effect on other blood cell lineages. We show that Crlf3-/- preplatelets have increased microtubule stability, possibly because of increased microtubule glutamylation via the interaction of CRLF3 with key members of the Hippo pathway. Using a mouse model of JAK2 V617F essential thrombocythemia, we show that a lack of CRLF3 leads to long-term lineage-specific normalization of the platelet count. We thereby postulate that targeting CRLF3 has therapeutic potential for treatment of thrombocythemia.
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CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia.,Bennett C, Lawrence M, Guerrero JA, Stritt S, Waller AK, Yan Y, Mifsud RW, Ballester-Beltran J, Baig A, Mueller A, Mayer L, Warland J, Penkett CJ, Akbari P, Moreau T, Evans AL, Mookerjee S, Hoffman GJ, Saeb-Parsy K, Adams DJ, Couzens AL, Bender M, Erber WN, Nieswandt B, Read RJ, Ghevaert C Blood. 2022 Apr 7;139(14):2227-2239. doi: 10.1182/blood.2021013113. PMID:35051265<ref>PMID:35051265</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6rpz" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bennett, C]]
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[[Category: Mus musculus]]
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[[Category: Mifsud, R W]]
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[[Category: Bennett C]]
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[[Category: Read, R J]]
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[[Category: Mifsud RW]]
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[[Category: Yan, Y]]
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[[Category: Read RJ]]
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[[Category: Blood clotting]]
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[[Category: Yan Y]]
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[[Category: Fibronectin domain]]
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[[Category: Platelet development]]
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[[Category: Spry domain]]
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Current revision

Cytokine receptor-like factor 3 C-terminus residues 174-442: native collected with 1.7A wavelength

PDB ID 6rpz

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