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4b8z

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<StructureSection load='4b8z' size='340' side='right'caption='[[4b8z]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='4b8z' size='340' side='right'caption='[[4b8z]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b8z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b8z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B8Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4b8w|4b8w]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/GDP-L-fucose_synthase GDP-L-fucose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.271 1.1.1.271] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8z OCA], [https://pdbe.org/4b8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b8z RCSB], [https://www.ebi.ac.uk/pdbsum/4b8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8z OCA], [http://pdbe.org/4b8z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b8z RCSB], [http://www.ebi.ac.uk/pdbsum/4b8z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FCL_HUMAN FCL_HUMAN]] Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
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[https://www.uniprot.org/uniprot/FCL_HUMAN FCL_HUMAN] Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: GDP-L-fucose synthase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Bunkoczi, G]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Rojkova A]]
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[[Category: Rojkova, A]]
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[[Category: Shafqat N]]
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[[Category: Shafqat, N]]
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[[Category: Vollmar M]]
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[[Category: Vollmar, M]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Yue WW]]
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[[Category: Yue, W W]]
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[[Category: Von Delft F]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, rhombohedral crystal form

PDB ID 4b8z

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