WD repeat-containing protein

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*'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes.
*'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes.
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*'''WD repeat-containing protein 41''' is the non-catalytic component of C9orf72-SMCR8 complex which regulates autophagy<ref>PMID:27193190</ref>. <br />
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*'''WD repeat-containing protein 55''' is a modulator of rRNA synthesis. <br />
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*'''WD repeat-containing protein 61''' is a component of PAF1 complex which functions during RNA transcription. <br />
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*'''WD repeat-containing protein 91''' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>. <br />
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*'''WD repeat-containing protein 92''' is a modulator of apoptosis. <br />
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*'''WD repeat-containing protein SLP1''' is required for mad2-dependent spindle checkpoint activation. <br />
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*'''WD repeat protein CSA''' or '''DNA excision repair protein ERCC-8''' is part of the transcription-coupled repair complex<ref>PMID:32355176</ref>. <br />
== Disease ==
== Disease ==
Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.
Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.
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== Structural highlights ==
== Structural highlights ==
The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres.
The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres.
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== 3D Structures of WD-repeat protein ==
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[[WD-repeat protein 3D structures]]
</StructureSection>
</StructureSection>
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== 3D Structures of WD-repeat protein ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*WDR5
 
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**[[2gnq]], [[2h68]], [[2h14]], [[2h9l]] – hWDR5 – human<br />
 
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**[[3mxx]], [[3n0d]], [[3n0e]] – hWDR5 (mutant)<br />
 
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**[[3smr]], [[3ur4]], [[4ia9]], [[4qqe]], [[4ql1]], [[5eal]], [[5eam]], [[5eap]], [[5ear]] – hWDR5 + piperazine derivative<br />
 
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**[[6u5m]], [[6u5y]], [[6u6w]], [[6u80]], [[6u8b]], [[6u8l]], [[6u8o]] – hWDR5 + sulfonamide inhibitor<br />
 
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**[[6ufx]], [[6ucs]], [[6pg3]], [[6pg4]], [[6pg5]], [[6pg6]], [[6pg7]], [[6pg8]], [[6pg9]], [[6pga]], [[6pgb]], [[6pgc]], [[6pgd]], [[6pge]], [[6pgf]], [[5vfc]], [[6dar]], [[6das]], [[6d9x]], [[6dai]], [[6dak]], [[6e1z]], [[6e1y]], [[6e22]], [[6e23]] – hWDR5 + inhibitor<br />
 
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**[[2cnx]], [[2co0]], [[2h6k]], [[2h6n]], [[2h6q]], [[2h13]], [[2h9m]], [[2h9n]], [[2h9p]], [[2g99]], [[2g9a]], [[2o9k]], [[3psl]], [[4a7j]] – hWDR5 + histone H3 peptide<br />
 
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**[[4gm3]], [[4gm8]], [[4gm9]], [[4gmb]] – hWDR5 + peptide inhibitor<br />
 
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**[[2xl2]], [[2xl3]] – hWDR5 + retinoblastoma-binding protein 5 peptide<br />
 
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**[[4o45]] – hWDR5 + influenza NS1 C-terminal<br />
 
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**[[4cy1]] – hWDR5 + KAT8 regulatory NSL complex subunit 1+2 peptides<br />
 
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**[[4cy2]] – hWDR5 + KAT8 regulatory NSL complex subunit 1 peptide<br />
 
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**[[4y7r]] – hWDR5 + Myc MbIIIb peptide<br />
 
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**[[3eg6]], [[3emh]], [[3uvk]], [[3uvl]], [[3uvm]], [[3uvn]], [[3uvo]], [[4erq]], [[4ery]], [[4es0]], [[4esg]], [[4ewr]], [[5sxm]] – hWDR5 + MLL peptide<br />
 
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**[[4erz]] – hWDR5 + MLL4<br />
 
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**[[6kiv]], [[6kiz]], [[6kiu]], [[6kix]] – hWDR5 in MLL1-ubNCP complex - Cryo EM<br />
 
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**[[6kiw]] – hWDR5 in MLL3-ubNCP complex - Cryo EM<br />
 
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**[[6pww]], [[6pwv]] – hWDR5 + MLL1 + RbBP5 + histones - Cryo EM<br />
 
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**[[6byn]] – hWDR5 + monobody<br />
 
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**[[3p4f]] – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide<br />
 
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**[[6iam]] – hWDR5 + small ubiquitin-related modifier 5<br />
 
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*WDR9
 
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**[[2q2e]] – hWDR9 residues 1310-1430<br />
 
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*WDR12
 
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**[[6p0q]] – hWDR12 UBL domain residues 1-87<br />
 
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**[[6n31]] – hWDR12 residues 90-422<br />
 
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*WDR20
 
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**[[5k19]] – hWDR20<br />
 
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*WDR33 or pre-mRNA 3' end processing protein WDR33
 
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**[[6f9n]] – hWDR33 residues 35-410 + CPSF160<br />
 
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**[[6urg]] – hWDR33 + CPSF160 + CPSF30 + CPSF100 - Cryo EM<br />
 
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**[[6fbs]], [[6fuw]], [[6uro]] – hWDR33 + CPSF160 + CPSF30 + PAS motif - Cryo EM<br />
 
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*WDR48
 
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**[[5cvl]] – hWDR48 <br />
 
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**[[5l8e]] – hWDR48 + peptide<br />
 
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**[[5l8w]], [[5cvn]], [[5cvo]] – hWDR48 + ubiquitin + ubiquitin carboxyl-terminal hydrolase<br />
 
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**[[5k1a]], [[5k1b]] – hWDR48 + ubiquitin carboxyl-terminal hydrolase<br />
 
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**[[5k1c]], [[6jlq]] – hWDR48 + WDR20 + ubiquitin carboxyl-terminal hydrolase<br />
 
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*WDR60
 
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**[[6rlb]], [[6sc2]] – hWDR60 + WDR34 + dynein + O6-alkylguanine-DNA alkyktransferase - Cryo EM<br />
 
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*WDR61
 
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**[[3ow8]] – hWDR61<br />
 
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*WDR91
 
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**[[6vyc]] – hWDR91 residues 392-747<br />
 
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*WDR92
 
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**[[3i2n]] – hWDR92<br />
 
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*WDR SLP1
 
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**[[4aez]] – WDR + mitotic spindle checkpoint component mad2-mad3 - fission yeast <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human WD-repeat protein 5 (deepskyblue) complex with histone H3 peptide (magenta) (PDB code 2h9m)

Drag the structure with the mouse to rotate

References

  1. ↑ Li D, Roberts R. WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases. Cell Mol Life Sci. 2001 Dec;58(14):2085-97. PMID:11814058
  2. ↑ Gan Q, Thiebaud P, Theze N, Jin L, Xu G, Grant P, Owens GK. WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. J Biol Chem. 2011 Jun 17;286(24):21853-64. doi: 10.1074/jbc.M111.233098. Epub, 2011 Apr 28. PMID:21531708 doi:http://dx.doi.org/10.1074/jbc.M111.233098
  3. ↑ Sullivan PM, Zhou X, Robins AM, Paushter DH, Kim D, Smolka MB, Hu F. The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. Acta Neuropathol Commun. 2016 May 18;4(1):51. doi: 10.1186/s40478-016-0324-5. PMID:27193190 doi:http://dx.doi.org/10.1186/s40478-016-0324-5
  4. ↑ Rapiteanu R, Davis LJ, Williamson JC, Timms RT, Paul Luzio J, Lehner PJ. A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin. Traffic. 2016 Aug;17(8):940-58. doi: 10.1111/tra.12409. Epub 2016 May 25. PMID:27126989 doi:http://dx.doi.org/10.1111/tra.12409
  5. ↑ van der Weegen Y, Golan-Berman H, Mevissen TET, Apelt K, González-Prieto R, Goedhart J, Heilbrun EE, Vertegaal ACO, van den Heuvel D, Walter JC, Adar S, Luijsterburg MS. The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II. Nat Commun. 2020 Apr 30;11(1):2104. PMID:32355176 doi:10.1038/s41467-020-15903-8
  6. ↑ Tullio-Pelet A, Salomon R, Hadj-Rabia S, Mugnier C, de Laet MH, Chaouachi B, Bakiri F, Brottier P, Cattolico L, Penet C, Begeot M, Naville D, Nicolino M, Chaussain JL, Weissenbach J, Munnich A, Lyonnet S. Mutant WD-repeat protein in triple-A syndrome. Nat Genet. 2000 Nov;26(3):332-5. PMID:11062474 doi:http://dx.doi.org/10.1038/81642
  7. ↑ Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J. Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO J. 2006 Sep 20;25(18):4245-52. Epub 2006 Aug 31. PMID:16946699

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