1avo

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[[Image:1avo.jpg|left|200px]]
 
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==PROTEASOME ACTIVATOR REG(ALPHA)==
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The line below this paragraph, containing "STRUCTURE_1avo", creates the "Structure Box" on the page.
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<StructureSection load='1avo' size='340' side='right'caption='[[1avo]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1avo]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AVO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1avo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1avo OCA], [https://pdbe.org/1avo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1avo RCSB], [https://www.ebi.ac.uk/pdbsum/1avo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1avo ProSAT]</span></td></tr>
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{{STRUCTURE_1avo| PDB=1avo | SCENE= }}
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</table>
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== Function ==
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'''PROTEASOME ACTIVATOR REG(ALPHA)'''
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[https://www.uniprot.org/uniprot/PSME1_HUMAN PSME1_HUMAN] Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The specificity of the 20S proteasome, which degrades many intracellular proteins, is regulated by protein complexes that bind to one or both ends of the cylindrical proteasome structure. One of these regulatory complexes, the 11S regulator (known as REG or PA28), stimulates proteasome peptidase activity and enhances the production of antigenic peptides for presentation by class I molecules of the major histocompatibility complex (MHC). The three REG subunits that have been identified, REGalpha, REGbeta and REGgamma (also known as the Ki antigen), share extensive sequence similarity, apart from a highly variable internal segment of 17-34 residues which may confer subunit-specific properties. REGalpha and REGbeta preferentially form a heteromeric complex, although purified REGalpha forms a heptamer in solution and has biochemical properties similar to the heteromeric REGalpha/REGbeta complex. We have now determined the crystal structure of human recombinant REGalpha at 2.8 A resolution. The heptameric barrel-shaped assembly contains a central channel that has an opening of 20 A diameter at one end and another of 30 A diameter at the presumed proteasome-binding surface. The binding of REG probably causes conformational changes that open a pore in the proteasome alpha-subunits through which substrates and products can pass.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/av/1avo_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1AVO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AVO OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1avo ConSurf].
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Structure of the proteasome activator REGalpha (PA28alpha)., Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang Z, Rechsteiner M, Hill CP, Nature. 1997 Dec 11;390(6660):639-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9403698 9403698]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Hill, C P.]]
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[[Category: Hill CP]]
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[[Category: Knowlton, J R.]]
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[[Category: Knowlton JR]]
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[[Category: Cell adhesion]]
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[[Category: Interferon induction]]
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[[Category: Proteasome activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:44:58 2008''
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Current revision

PROTEASOME ACTIVATOR REG(ALPHA)

PDB ID 1avo

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