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6vyi

From Proteopedia

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Current revision (14:40, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6vyi is ON HOLD until Paper Publication
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==Cryo-EM structure of human diacylglycerol O-acyltransferase 1==
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<StructureSection load='6vyi' size='340' side='right'caption='[[6vyi]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6vyi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VYI FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OU:[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl]+(~{Z})-octadec-9-enoate'>6OU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vyi OCA], [https://pdbe.org/6vyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vyi RCSB], [https://www.ebi.ac.uk/pdbsum/6vyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vyi ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DGAT1_HUMAN DGAT1_HUMAN] Congenital chronic diarrhea with protein-losing enteropathy. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/DGAT1_HUMAN DGAT1_HUMAN] Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.<ref>PMID:16214399</ref> <ref>PMID:9756920</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Farese VR]]
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[[Category: Gluchowski N]]
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[[Category: Liao M]]
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[[Category: Sui X]]
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[[Category: Walther CT]]
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[[Category: Wang K]]

Current revision

Cryo-EM structure of human diacylglycerol O-acyltransferase 1

PDB ID 6vyi

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