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6pgr

From Proteopedia

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<StructureSection load='6pgr' size='340' side='right'caption='[[6pgr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='6pgr' size='340' side='right'caption='[[6pgr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pgr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PGR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PGR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8XY:6-bromo-N-(1H-indol-4-yl)-1-benzothiophene-2-carboxamide'>8XY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v15|5v15]], [[5v4j|5v4j]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8XY:6-bromo-N-(1H-indol-4-yl)-1-benzothiophene-2-carboxamide'>8XY</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.46 2.5.1.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgr OCA], [https://pdbe.org/6pgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pgr RCSB], [https://www.ebi.ac.uk/pdbsum/6pgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgr OCA], [http://pdbe.org/6pgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pgr RCSB], [http://www.ebi.ac.uk/pdbsum/6pgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DHYS_HUMAN DHYS_HUMAN]] Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
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[https://www.uniprot.org/uniprot/DHYS_HUMAN DHYS_HUMAN] Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6pgr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6pgr" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Deoxyhypusine synthase|Deoxyhypusine synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Ambrus-Aikelin G]]
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[[Category: Ambrus-Aikelin, G]]
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[[Category: Klein MG]]
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[[Category: Klein, M G]]
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[[Category: Deoxyhypusine]]
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[[Category: Inhibitor]]
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[[Category: Transferase-inhibitor complex]]
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Current revision

Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-BROMO-N-(1H-INDOL-4-YL)-1-BENZOTHIOPHENE-2-CARBOXAMIDE

PDB ID 6pgr

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