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6ohr

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Current revision (07:10, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6ohr' size='340' side='right'caption='[[6ohr]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='6ohr' size='340' side='right'caption='[[6ohr]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ohr]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OHR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ohr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OHR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MKG:4-fluoro-N-{(2S)-1-[(5R)-5-(3-fluorophenyl)-2-oxo-1-oxa-3,9-diazaspiro[5.5]undecan-9-yl]propan-2-yl}benzamide'>MKG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MKG:4-fluoro-N-{(2S)-1-[(5R)-5-(3-fluorophenyl)-2-oxo-1-oxa-3,9-diazaspiro[5.5]undecan-9-yl]propan-2-yl}benzamide'>MKG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_D Phospholipase D], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.4 3.1.4.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ohr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ohr OCA], [https://pdbe.org/6ohr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ohr RCSB], [https://www.ebi.ac.uk/pdbsum/6ohr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ohr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ohr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ohr OCA], [http://pdbe.org/6ohr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ohr RCSB], [http://www.ebi.ac.uk/pdbsum/6ohr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ohr ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PLD1_HUMAN PLD1_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/PLD1_HUMAN PLD1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PLD1_HUMAN PLD1_HUMAN]] Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
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[https://www.uniprot.org/uniprot/PLD1_HUMAN PLD1_HUMAN] Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6ohr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ohr" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase D 3D structures|Phospholipase D 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phospholipase D]]
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[[Category: Chodaparambil JV]]
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[[Category: Chodaparambil, J V]]
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[[Category: Metrick CM]]
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[[Category: Metrick, C M]]
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[[Category: Hkd motif]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Phosphodiesterase]]
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Current revision

Structure of compound 5 bound human Phospholipase D1 catalytic domain

PDB ID 6ohr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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