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Spike protein

From Proteopedia

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(New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for you...)
Current revision (10:15, 4 December 2023) (edit) (undo)
 
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==Your Heading Here (maybe something like 'Structure')==
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<StructureSection load='3kbh' size='340' side='right' caption='Human coronavirus NL63 spike glycoprotein (magenta) complex with its ligand ACE2 (green) (PDB code [[3kbh]])' scene='84/840522/Cv/2'>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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This is a default text for your page '''Spike protein'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Function ==
== Function ==
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The coronavirus '''spike protein''' (Spi, also called ''protein S'') binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus <ref>PMID:32075877</ref>. See also
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*[[Angiotensin-Converting Enzyme#ACEII and SARS|ACEII and SARS]]<br />
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*[[SARS-CoV-2 protein S]]<br />
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*[[SARS-CoV-2 spike protein mutations]]<br />
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*[[Coronavirus Disease 2019 (COVID-19)]]<br />
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* and the animation at [[SARS-CoV-2 protein S priming by furin]] and [[SARS-CoV-2 spike protein fusion transformation]]
== Disease ==
== Disease ==
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Numerous viral diseases are causing world-shattering consequences and the current pandemic of CoVID-2019 is the recent one.
== Relevance ==
== Relevance ==
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The spike protein is a key target for potential therapies and diagnostics. Various antibodies are currently being tested as potential CoVID-2019 antiviral treatment<ref>PMID:32065055</ref>.
== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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The SARS-CoV Spi receptor binding domain complex with its cellular receptor - ACE2 - shows the <scene name='84/840522/Cv/3'>interactions</scene> to ACE2 "hot spot"<ref>PMID:19901337</ref>.
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</StructureSection>
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== See Also ==
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*[[SARS-CoV-2 protein S]]
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*[[SARS-CoV-2 protein S priming by furin]] where the priming step induced by furin cleavage is '''animated'''.
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*[[SARS-CoV-2 spike protein fusion transformation]] with an '''animation''' and explanation of the membrane fusion mechanism.
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*[[SARS-CoV-2 spike protein mutations]]
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*[[Coronavirus Disease 2019 (COVID-19)]]
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*[[User:Andre Wu Le Chun/Sandbox 1|Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up]] about [[6vsb]]
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*[[Spike Protein (Hebrew)]]
== 3D Structures of spike protein ==
== 3D Structures of spike protein ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Spike protein 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Flagellin
 
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**[[5wrg]], [[5xlr]] – hscvSpi – human SARS coronavirus virus – Cryo EM <br />
 
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**[[1wnc]] – hscvSpi fusion core 900-1184<br />
 
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**[[2ghv]] – hscvSpi RBD 318-510<br />
 
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**[[6u7h]] – Spi – human coronavirus 229E virus – Cryo EM <br />
 
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**[[5x4r]], [[5x4s]] – Spi N-terminal – MERS coronavirus virus – Cryo EM <br />
 
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**[[4h14]] – Spi lectin domain 7-290 - bovine coronavirus<br />
 
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**[[6u7k]] – Spi – porcine epidemic diarrhea virus – Cryo EM <br />
 
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**[[1wdf]], [[1wdg]] – Spi – murine hepatitis virus<br />
 
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**[[5gyq]] – Spi RBD - bat coronavirus<br />
 
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**[[6orj]] – Spi - Pseudomonas virus phikz164i<br />
 
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}}
 
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[[Category:Topic Page]]
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
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[[Category:Topic Page]]

Current revision

Human coronavirus NL63 spike glycoprotein (magenta) complex with its ligand ACE2 (green) (PDB code 3kbh)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Eric Martz, Joel L. Sussman

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