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Spike protein
From Proteopedia
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| - | + | <StructureSection load='3kbh' size='340' side='right' caption='Human coronavirus NL63 spike glycoprotein (magenta) complex with its ligand ACE2 (green) (PDB code [[3kbh]])' scene='84/840522/Cv/2'> | |
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== Function == | == Function == | ||
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| + | The coronavirus '''spike protein''' (Spi, also called ''protein S'') binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus <ref>PMID:32075877</ref>. See also | ||
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| + | *[[Angiotensin-Converting Enzyme#ACEII and SARS|ACEII and SARS]]<br /> | ||
| + | *[[SARS-CoV-2 protein S]]<br /> | ||
| + | *[[SARS-CoV-2 spike protein mutations]]<br /> | ||
| + | *[[Coronavirus Disease 2019 (COVID-19)]]<br /> | ||
| + | * and the animation at [[SARS-CoV-2 protein S priming by furin]] and [[SARS-CoV-2 spike protein fusion transformation]] | ||
== Disease == | == Disease == | ||
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| + | Numerous viral diseases are causing world-shattering consequences and the current pandemic of CoVID-2019 is the recent one. | ||
== Relevance == | == Relevance == | ||
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| + | The spike protein is a key target for potential therapies and diagnostics. Various antibodies are currently being tested as potential CoVID-2019 antiviral treatment<ref>PMID:32065055</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| - | + | The SARS-CoV Spi receptor binding domain complex with its cellular receptor - ACE2 - shows the <scene name='84/840522/Cv/3'>interactions</scene> to ACE2 "hot spot"<ref>PMID:19901337</ref>. | |
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| - | + | == See Also == | |
| + | *[[SARS-CoV-2 protein S]] | ||
| + | *[[SARS-CoV-2 protein S priming by furin]] where the priming step induced by furin cleavage is '''animated'''. | ||
| + | *[[SARS-CoV-2 spike protein fusion transformation]] with an '''animation''' and explanation of the membrane fusion mechanism. | ||
| + | *[[SARS-CoV-2 spike protein mutations]] | ||
| + | *[[Coronavirus Disease 2019 (COVID-19)]] | ||
| + | *[[User:Andre Wu Le Chun/Sandbox 1|Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up]] about [[6vsb]] | ||
| + | *[[Spike Protein (Hebrew)]] | ||
== 3D Structures of spike protein == | == 3D Structures of spike protein == | ||
| - | + | [[Spike protein 3D structures]] | |
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| - | * Flagellin | ||
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| - | **[[5wrg]], [[5xlr]] – hscvSpi – human SARS coronavirus – Cryo EM <br /> | ||
| - | **[[6crv]], [[6crw]], [[6crx]], [[6crz]] – hscvSpi (mutant) – Cryo EM <br /> | ||
| - | **[[1wnc]] – hscvSpi fusion core 900-1184<br /> | ||
| - | **[[2ghv]] – hscvSpi RBD 318-510<br /> | ||
| - | **[[1wyy]] – hscvSpi 885-1189<br /> | ||
| - | **[[2ajf]] – hscvSpi RBD + ACHE<br /> | ||
| - | **[[2ghw]] – hscvSpi RBD + antibody<br /> | ||
| - | **[[6u7h]] – hcv229Spi – human coronavirus 229E – Cryo EM <br /> | ||
| - | **[[6atk]] – hcv229Spi RBD + aminopeptidase <br /> | ||
| - | **[[5x58]], [[5x5b]] – Spi – human SARS coronavirus BJ01 – Cryo EM <br /> | ||
| - | **[[6vsb]], [[6vxx]], [[6vyb]] – hsc2Spi – human SARS coronavirus 2 – Cryo EM <br /> | ||
| - | **[[6m0j]] – hsc2Spi RBD + ACE2<br /> | ||
| - | **[[5szs]] – hcnSpi – human coronavirus NL63 - Cryo EM<br /> | ||
| - | **[[2ieq]] – hcnSpi residues 981-1038, 1242-1283 <br /> | ||
| - | **[[6cv0]] – Spi – infectious bronchitis coronavirus – Cryo EM <br /> | ||
| - | **[[5fyn]] – Spi ectodomain - puumala virus - Cryo EM<br /> | ||
| - | **[[5x59]], [[5x5c]], [[5x5f]] – McvSpi – MERS coronavirus virus – Cryo EM <br /> | ||
| - | **[[5x4r]], [[5x4s]] – McvSpi N-terminal – Cryo EM <br /> | ||
| - | **[[4zpw]], [[4kqz]] – McvSpi RBD<br /> | ||
| - | **[[4kr0]] – McvSpi RBD + CD26<br /> | ||
| - | **[[6pz8]] – McvSpi + antibody – Cryo EM <br /> | ||
| - | **[[6j11]] – McvSpi N-terminal + antibody<br /> | ||
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| - | **[[4h14]] – Spi lectin domain 7-290 - bovine coronavirus<br /> | ||
| - | **[[6b7n]] – Spi – porcine delta coronavirus – Cryo EM <br /> | ||
| - | **[[6u7k]], [[6vv5]] – Spi – porcine epidemic diarrhea virus – Cryo EM <br /> | ||
| - | **[[6qfy]] – Spi lectin domain 15-300 - porcine hemagglutinating encephalomyelitis virus<br /> | ||
| - | **[[6jhy]] – Spi N-terminal – camel coronavirus HKU23<br /> | ||
| - | **[[1wdf]], [[1wdg]] – mhvSpi – murine hepatitis virus<br /> | ||
| - | **[[6b3o]] – Spi residues 718-1252 – murine coronavirus - Cryo EM<br /> | ||
| - | **[[3jcl]] – mhvSpi – Cryo EM<br /> | ||
| - | **[[5gyq]] – bcvSpi RBD - bat coronavirus<br /> | ||
| - | **[[5xgr]] – bcvSpi C-terminal<br /> | ||
| - | **[[6orj]] – Spi - Pseudomonas virus phikz164i<br /> | ||
| - | **[[2vvd]], [[2vve]] – Spi RBD - Pseudoalteromonas phage PM2<br /> | ||
| - | **[[3aqj]] – Spi 87-211 - Enterobacteria phage P2<br /> | ||
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| - | }} | ||
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| - | [[Category:Topic Page]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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| + | </StructureSection> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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