6kze
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structue of PDE10A complexed with 4d== |
| + | <StructureSection load='6kze' size='340' side='right'caption='[[6kze]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6kze]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KZE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5000348Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DZU:8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline'>DZU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kze OCA], [https://pdbe.org/6kze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kze RCSB], [https://www.ebi.ac.uk/pdbsum/6kze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kze ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Guo | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Luo | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Guo L]] |
| - | [[Category: | + | [[Category: Huang Y-Y]] |
| + | [[Category: Luo H-B]] | ||
| + | [[Category: Yang Y]] | ||
| + | [[Category: Zhang S]] | ||
| + | [[Category: Zhou Q]] | ||
Current revision
The crystal structue of PDE10A complexed with 4d
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Categories: Homo sapiens | Large Structures | Guo L | Huang Y-Y | Luo H-B | Yang Y | Zhang S | Zhou Q
