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6lkg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==two-component system protein mediate signal transduction== | |
| - | + | <StructureSection load='6lkg' size='340' side='right'caption='[[6lkg]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6lkg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LKG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.948Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lkg OCA], [https://pdbe.org/6lkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lkg RCSB], [https://www.ebi.ac.uk/pdbsum/6lkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lkg ProSAT]</span></td></tr> |
| - | [[Category: Tao | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HPTS_STAA8 HPTS_STAA8] Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources (PubMed:25644013). May act as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of HptS. In turn, HptS antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility (PubMed:30540769).<ref>PMID:25644013</ref> <ref>PMID:30540769</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Staphylococcus aureus]] | ||
| + | [[Category: Staphylococcus aureus subsp. aureus NCTC 8325]] | ||
| + | [[Category: Tao Y]] | ||
| + | [[Category: Wang M]] | ||
Current revision
two-component system protein mediate signal transduction
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