6wc9

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(New page: '''Unreleased structure''' The entry 6wc9 is ON HOLD Authors: Oh, S., Paknejad, N., Hite, R.K. Description: Human open state TMEM175 in KCl Category: Unreleased Structures [[Catego...)
Current revision (14:42, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6wc9 is ON HOLD
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==Human open state TMEM175 in KCl==
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<StructureSection load='6wc9' size='340' side='right'caption='[[6wc9]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
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Authors: Oh, S., Paknejad, N., Hite, R.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6wc9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WC9 FirstGlance]. <br>
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Description: Human open state TMEM175 in KCl
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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[[Category: Paknejad, N]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wc9 OCA], [https://pdbe.org/6wc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wc9 RCSB], [https://www.ebi.ac.uk/pdbsum/6wc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wc9 ProSAT]</span></td></tr>
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[[Category: Hite, R.K]]
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</table>
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[[Category: Oh, S]]
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== Disease ==
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[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. TMEM175 defects result in unstable lysosomal pH, leading to decreased lysosomal catalytic activity, decreased glucocerebrosidase activity, impaired autophagosome clearance by the lysosome and decreased mitochondrial respiration (PubMed:28193887).<ref>PMID:28193887</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.<ref>PMID:26317472</ref> <ref>PMID:28723891</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hite RK]]
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[[Category: Oh S]]
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[[Category: Paknejad N]]

Current revision

Human open state TMEM175 in KCl

PDB ID 6wc9

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