6vkz
From Proteopedia
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<StructureSection load='6vkz' size='340' side='right'caption='[[6vkz]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='6vkz' size='340' side='right'caption='[[6vkz]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6vkz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VKZ OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6vkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudo-nitzschia_multiseries Pseudo-nitzschia multiseries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VKZ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GST:GERANYL+S-THIOLODIPHOSPHATE'>GST</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GST:GERANYL+S-THIOLODIPHOSPHATE'>GST</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vkz OCA], [https://pdbe.org/6vkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vkz RCSB], [https://www.ebi.ac.uk/pdbsum/6vkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vkz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DABA_PSEMU DABA_PSEMU] Magnesium-dependent glutamate N-prenyltransferase: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP) (PubMed:30262498). Catalyzes the conversion of L-glutamic acid (L-Glu) to N-geranyl-L-glutamic acid (NGG) in the presence of geranyl diphosphate (GPP) (PubMed:30262498, PubMed:32457155). Also able to catalyze the formation of farnesyl-L-glutamate from farnesyl diphosphate (FPP) (PubMed:32457155). Cannot use dimethylallyl diphosphate (DMAPP) as substrate (PubMed:32457155).<ref>PMID:30262498</ref> <ref>PMID:32457155</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Pseudo-nitzschia multiseries]] |
| - | [[Category: | + | [[Category: Chekan JR]] |
| - | [[Category: | + | [[Category: Moore BS]] |
| - | [[Category: | + | [[Category: Noel JP]] |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of the N-prenyltransferase DabA in Complex with GSPP and Mg2+
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