6vo2

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<StructureSection load='6vo2' size='340' side='right'caption='[[6vo2]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='6vo2' size='340' side='right'caption='[[6vo2]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6vo2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VO2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VO2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6vo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VO2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=R67:3-(methylsulfonyl)-2-oxopropanoic+acid'>R67</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketol-acid_reductoisomerase Ketol-acid reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.86 1.1.1.86] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=R67:3-(methylsulfonyl)-2-oxopropanoic+acid'>R67</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vo2 OCA], [http://pdbe.org/6vo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vo2 RCSB], [http://www.ebi.ac.uk/pdbsum/6vo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vo2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vo2 OCA], [https://pdbe.org/6vo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vo2 RCSB], [https://www.ebi.ac.uk/pdbsum/6vo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vo2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A145BYP4_STAAU A0A145BYP4_STAAU]] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435][SAAS:SAAS00826005]
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[https://www.uniprot.org/uniprot/ILVC_STAA8 ILVC_STAA8] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6vo2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6vo2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ketol-acid reductoisomerase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bayaraa, T]]
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[[Category: Staphylococcus aureus]]
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[[Category: Guddat, L W]]
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[[Category: Bayaraa T]]
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[[Category: Patel, K M]]
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[[Category: Guddat LW]]
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[[Category: Complex]]
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[[Category: Patel KM]]
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[[Category: Inhibitor]]
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[[Category: Metal binding protein]]
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[[Category: Reductoisomerase]]
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Current revision

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg, NADPH and inhibitor.

PDB ID 6vo2

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